Liu Lishi, Meng Zihan, Yan Jun
The Second Department of Oncology, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China.
PLoS One. 2025 Feb 6;20(2):e0318984. doi: 10.1371/journal.pone.0318984. eCollection 2025.
Chemotherapy-related cognitive impairment (CRCI) is a common adverse effect of chemotherapy in breast cancer patients, with a high incidence that significantly impacts treatment adherence and quality of life. Currently, there is no definitive and effective treatment for CRCI. Research indicates that acupuncture may serve as a promising intervention for CRCI. This study aims to assess the effectiveness of acupuncture in treating CRCI.
This study is guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols (PRISMA-P). From the time of database construction to October 2024, we will search seven literature databases, three clinical study registry databases, and three sources of gray literature. The restricted languages are English and Chinese. We will use the Participants-Interventions-Comparators-Outcome-Conclusion-Study Design (PICOS) criteria to identify included studies and the RoB2 tool to assess the quality of the included studies. Data synthesis and meta-analysis will be performed using RevMan 5.3.
The results of this study will clarify the potential benefits of acupuncture in the treatment of CRCI and address existing disagreements about its efficacy. Furthermore, the findings will assist clinicians in making informed decisions regarding the treatment of CRCI.
PROSPERO registration number: CRD42024568093.
化疗相关认知障碍（CRCI）是乳腺癌患者化疗常见的不良反应，发病率高，严重影响治疗依从性和生活质量。目前，尚无针对CRCI的确切有效治疗方法。研究表明，针灸可能是治疗CRCI的一种有前景的干预措施。本研究旨在评估针灸治疗CRCI的有效性。
本研究以系统评价和Meta分析方案的首选报告项目（PRISMA-P）为指导。从数据库构建之时至2024年10月，我们将检索七个文献数据库、三个临床研究注册数据库和三个灰色文献来源。限定语言为英语和中文。我们将使用参与者-干预措施-对照-结局-结论-研究设计（PICOS）标准来识别纳入研究，并使用RoB2工具评估纳入研究的质量。将使用RevMan 5.3进行数据合成和Meta分析。
本研究结果将阐明针灸治疗CRCI的潜在益处，并解决关于其疗效的现有分歧。此外，研究结果将帮助临床医生就CRCI的治疗做出明智决策。
PROSPERO注册号：CRD42024568093。
