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一名孕妇出现出血表现及视力障碍的颅咽管瘤。病例报告及文献综述。

Craniopharyngioma with hemorrhagic presentation and visual impairment in a pregnant woman. Case report and literature review.

作者信息

Ardila Botero Daniel Andrés, Céspedes Trujillo Laura

机构信息

Departamento de Ginecología y Obstetricia, Unidad Materno Infantil del Tolima (UMIT). Ibagué (Colombia).

出版信息

Rev Colomb Obstet Ginecol. 2024 Nov 25;75(4):4215. doi: 10.18597/rcog.4215.

DOI:10.18597/rcog.4215
PMID:39913792
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11812093/
Abstract

OBJECTIVES

To present the case of a pregnant woman diagnosed with craniopharyngioma and to review the literature on the diagnosis, treatment, and maternal-perinatal outcomes of this type of tumor.

MATERIAL AND METHODS

A 41-year-old multigravida at 23.6 weeks of gestation was admitted to a high-complexity private clinic due to significant bilateral visual acuity reduction and headache. A diagnosis of craniopharyngioma was made, and expectant management was chosen. The patient underwent an uncomplicated cesarean delivery. The literature review included case reports and series on pregnant women diagnosed with craniopharyngioma. Literature was searched on PubMed, EBSCO, and Scopus, along with references from the selected studies. A narrative summary of the findings is provided.

RESULTS

Ten case reports were included. All patients presented with visual disturbances, and eight cases had diabetes insipidus. Magnetic resonance imaging (MRI) was used in nine cases, effectively identifying the tumor. Seven patients underwent craniotomy (four during pregnancy, two postpartum, and one post-abortion), while three had transsphenoidal surgery (two during pregnancy and one postpartum). Three cases experienced tumor recurrence, and two had incomplete resection. During the postpartum period, 9 cases had resolution of visual symptoms. In four cases, follow-up ranged from two to six years without evidence of recurrence.

CONCLUSIONS

In pregnant women with bitemporal hemianopsia, a possible suprasellar tumor should be suspected. MRI of the brain and sella turcica is the diagnostic modality of choice. Further studies are needed to document this condition in pregnancy and its obstetric management in greater detail.

摘要

目的

介绍一例被诊断为颅咽管瘤的孕妇病例,并回顾关于此类肿瘤的诊断、治疗及母婴围产期结局的文献。

材料与方法

一名41岁、孕23.6周的经产妇因双侧视力显著下降和头痛入住一家高复杂性私立诊所。诊断为颅咽管瘤,并选择了期待治疗。患者顺利进行了剖宫产。文献综述包括诊断为颅咽管瘤的孕妇的病例报告和系列研究。在PubMed、EBSCO和Scopus上进行文献检索,并参考所选研究的参考文献。提供了研究结果的叙述性总结。

结果

纳入了10例病例报告。所有患者均有视觉障碍,8例有尿崩症。9例使用了磁共振成像(MRI),有效识别了肿瘤。7例患者接受了开颅手术(4例在孕期,2例产后,1例流产后),3例接受了经蝶窦手术(2例在孕期,1例产后)。3例出现肿瘤复发,2例切除不完全。产后,9例视觉症状缓解。4例随访2至6年,无复发迹象。

结论

对于出现双颞侧偏盲的孕妇,应怀疑可能存在鞍上肿瘤。脑部和蝶鞍的MRI是首选的诊断方法。需要进一步研究以更详细地记录孕期的这种情况及其产科管理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0874/11812093/646ec7df2bd2/2463-0225-rcog-75-04-4215-gf2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0874/11812093/8b57d58e325c/2463-0225-rcog-75-04-4215-gf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0874/11812093/646ec7df2bd2/2463-0225-rcog-75-04-4215-gf2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0874/11812093/8b57d58e325c/2463-0225-rcog-75-04-4215-gf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0874/11812093/646ec7df2bd2/2463-0225-rcog-75-04-4215-gf2.jpg

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Rev Colomb Obstet Ginecol. 2024 Nov 25;75(4):4215. doi: 10.18597/rcog.4215.
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本文引用的文献

1
A Rare Occurrence of Craniopharyngioma Causing Visual Disturbance in Pregnancy.孕期罕见颅咽管瘤致视力障碍
Cureus. 2021 Oct 12;13(10):e18700. doi: 10.7759/cureus.18700. eCollection 2021 Oct.
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The 2021 WHO Classification of Tumors of the Central Nervous System: a summary.2021 年世卫组织中枢神经系统肿瘤分类:概述。
Neuro Oncol. 2021 Aug 2;23(8):1231-1251. doi: 10.1093/neuonc/noab106.
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Craniopharyngioma.颅咽管瘤。
Nat Rev Dis Primers. 2019 Nov 7;5(1):75. doi: 10.1038/s41572-019-0125-9.
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Surgical indications for pituitary tumors during pregnancy: a literature review.妊娠期间垂体瘤的手术适应证:文献综述。
Pituitary. 2020 Apr;23(2):189-199. doi: 10.1007/s11102-019-01004-3.
5
Advances in the management of craniopharyngioma in children and adults.儿童和成人颅咽管瘤的治疗进展。
Radiol Oncol. 2019 Oct 25;53(4):388-396. doi: 10.2478/raon-2019-0036.
6
Craniopharyngioma: long-term consequences of a chronic disease.颅咽管瘤:一种慢性疾病的长期后果
Expert Rev Neurother. 2015;15(11):1241-4. doi: 10.1586/14737175.2015.1100078. Epub 2015 Nov 2.
7
Haemorrhagic presentation of a craniopharyngioma in a pregnant woman.一名孕妇颅咽管瘤的出血表现。
Case Rep Neurol Med. 2014;2014:435208. doi: 10.1155/2014/435208. Epub 2014 Aug 5.
8
[Practice guideline for diagnosis and treatment of craniopharyngioma and parasellar tumors of the pituitary gland].[颅咽管瘤及垂体鞍旁肿瘤诊断与治疗实践指南]
Endocrinol Nutr. 2015 Jan;62(1):e1-13. doi: 10.1016/j.endonu.2014.05.005. Epub 2014 Jul 22.
9
[Acute visual loss in pregnancy caused by craniopharyngioma].[颅咽管瘤导致的妊娠期急性视力丧失]
Arch Soc Esp Oftalmol. 2014 Apr;89(4):152-6. doi: 10.1016/j.oftal.2012.09.016. Epub 2012 Dec 20.
10
Incidence of craniopharyngioma in Denmark (n = 189) and estimated world incidence of craniopharyngioma in children and adults.丹麦颅咽管瘤发病率(n=189)和儿童及成人颅咽管瘤全球估计发病率。
J Neurooncol. 2011 Sep;104(3):755-63. doi: 10.1007/s11060-011-0540-6. Epub 2011 Feb 19.