Zhao Dian, Mei Bo, Zhu Liting, Wen Long, Zhou Chunyang
Eye School of Chengdu University of TCM, Chengdu, Sichuan, China.
Ineye Hospital of Chengdu University of TCM, Chengdu, Sichuan, China.
Eye (Lond). 2025 Jun;39(8):1465-1469. doi: 10.1038/s41433-025-03645-0. Epub 2025 Feb 6.
This study aimed to analyse the correlation between corneal astigmatism and disparity in corneal thickness.
In this retrospective analysis, data from 342 patients (684 eyes) were collected. The Sirius three-dimensional corneal topography system was utilised to ascertain the mean corneal thickness of the meridians. Correlation analyses were conducted between the mean difference in corneal thickness along the two principal meridians and the astigmatic values computed by simulated keratometry values (Sim-K) for total corneal astigmatism (TCA) and posterior corneal astigmatism (PCA), respectively. Variability in differential corneal thickness (DCT) values at different TCA levels was analysed. The variability of DCT within the 3-mm corneal range at different differences between whole-eye astigmatism and TCA (Difference between corneal astigmatism and computer optometry, DWT) levels was analysed.
Within the ranges of 3, 4.5, and 6 mm, the mean corneal thickness of the meridian with the maximum refractive power (Sim-K) was greater than that of the meridian with the minimum refractive power (Sim-K) (P < 0.05). The TCA showed a negative correlation with DCT across all three ranges (P < 0.001), whereas PCA exhibited a positive correlation with DCT (P < 0.001). A difference was observed among the TCA groups within each range, with DCT increasing alongside the dioptre of astigmatism (P < 0.05). In the 3 mm corneal range, an increase in the difference in corneal thickness was associated with an increase in the difference between whole-eye astigmatism and TCA (P < 0.05).
The meridian with the maximum refractive power had a thicker mean corneal thickness than the meridian with the minimum refractive power. The difference in corneal thickness is closely related to the severity of corneal astigmatism. The extent of residual astigmatism is influenced by this thickness difference.
本研究旨在分析角膜散光与角膜厚度差异之间的相关性。
在这项回顾性分析中，收集了342例患者（684只眼）的数据。使用Sirius三维角膜地形图系统确定各子午线的平均角膜厚度。分别对两条主要子午线的角膜厚度平均差值与通过模拟角膜曲率计值（Sim-K）计算的总角膜散光（TCA）和后角膜散光（PCA）的散光值进行相关性分析。分析了不同TCA水平下角膜厚度差（DCT）值的变异性。分析了在全眼散光与TCA的不同差值（角膜散光与电脑验光差值，DWT）水平下，3mm角膜范围内DCT的变异性。
在3mm、4.5mm和6mm范围内，最大屈光力子午线（Sim-K）的平均角膜厚度大于最小屈光力子午线（Sim-K）的平均角膜厚度（P < 0.05）。在所有三个范围内，TCA与DCT均呈负相关（P < 0.001），而PCA与DCT呈正相关（P < 0.001）。在每个范围内的TCA组之间观察到差异，DCT随着散光度数的增加而增加（P < 0.05）。在3mm角膜范围内，角膜厚度差异的增加与全眼散光和TCA之间差异的增加相关（P < 0.05）。
最大屈光力子午线的平均角膜厚度比最小屈光力子午线厚。角膜厚度差异与角膜散光的严重程度密切相关。这种厚度差异会影响残余散光的程度。
