Bataille P, Pruna A, Finet I, Leflon P, Makdassi R, Galy C, Fievet P, Fournier A
Proc Eur Dial Transplant Assoc Eur Ren Assoc. 1985;21:747-50.
Plasma magnesium (PMg) and urinary calcium (UCaV) and magnesium (UMgV) were measured after four days of calcium-restricted diet in 60 controls and 82 patients classified according to their calcium excretion in three groups: normo-calciuric (NCa), dietary hypercalciuria (DH) and idiopathic hypercalciuria (IH). When compared to controls, higher UMgV (4.26 +/- 0.28 mmol/d versus 3.4 +/- 0.16, p less than 0.01), lower PMg (0.79 +/- 0.01 mmol/d versus 0.84 +/- 0.01, p less than 0.05) and lower UMg/UCa ratio (0.6 +/- 0.04 versus 1.68 +/- 0.15, p less than 0.001) were observed only in IH. A significant correlation between UMgV and UCaV was found in controls, in NCa and in DH but not in IH. In conclusion, (1) the coexistence of a higher UMgV and of a lower PMg in IH suggests that there is a magnesium depletion in this group of patients; (2) since the lower UMg/UCa ratio may favour a higher propensity for calcium crystallisation and is seen only in IH, magnesium supplements may be specially indicated in this group.
在60名对照者和82名患者中，根据钙排泄情况分为三组：正常钙尿组（NCa）、饮食性高钙尿组（DH）和特发性高钙尿组（IH），在进行4天限钙饮食后测量血浆镁（PMg）、尿钙（UCaV）和尿镁（UMgV）。与对照者相比，仅在特发性高钙尿组中观察到较高的尿镁排泄量（4.26±0.28 mmol/d对3.4±0.16，p<0.01）、较低的血浆镁（0.79±0.01 mmol/d对0.84±0.01，p<0.05）和较低的尿镁/尿钙比值（0.6±0.04对1.68±0.15，p<0.001）。在对照者、正常钙尿组和饮食性高钙尿组中发现尿镁排泄量与尿钙排泄量之间存在显著相关性，但在特发性高钙尿组中未发现。总之，（1）特发性高钙尿组中较高的尿镁排泄量和较低的血浆镁共存表明该组患者存在镁缺乏；（2）由于较低的尿镁/尿钙比值可能有利于钙结晶的更高倾向，且仅在特发性高钙尿组中出现，因此该组可能特别需要补充镁。
