Zeldich Dean, Bierowski Matthew, Shabo Leah, Yaddanapudi Sridhara, Marhefka Gregary
Department of Neurology, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Department of Internal Medicine, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
J Stroke. 2025 Jan;27(1):19-29. doi: 10.5853/jos.2024.02915. Epub 2025 Jan 31.
Acute aortic syndromes (AAS) such as aortic dissection, intramural hematoma, and penetrating aortic ulcer pose significant neurovascular risks, affecting patient outcomes. This review examines the incidence, clinical presentation, and outcomes of neurovascular complications in AAS patients. Common complications include stroke, spinal cord ischemia, and transient ischemic attacks, with stroke being the most prevalent. Managing aortic dissection necessitates careful blood pressure control to prevent dissection progression while avoiding compromised cerebral and spinal perfusion. Carotid involvement, particularly dissection, increases stroke and transient ischemic attack risks. Emergency surgical interventions, though essential to prevent rupture or repair dissection, carry risks of perioperative neurovascular complications. The use of electroencephalography and transcranial Doppler can aid in the early detection and monitoring of neurovascular events. We discuss the pros and cons of certain blood pressure medications in the acute treatment of aortic dissection. A multidisciplinary approach involving cardiovascular surgeons, neurologists, and critical care specialists is vital for optimizing outcomes and mitigating risks. Early recognition and management of neurovascular complications are crucial, and further research is needed to develop targeted prevention and treatment strategies.
急性主动脉综合征(AAS),如主动脉夹层、壁内血肿和穿透性主动脉溃疡,会带来重大的神经血管风险,影响患者的预后。本综述探讨了AAS患者神经血管并发症的发生率、临床表现和预后。常见并发症包括中风、脊髓缺血和短暂性脑缺血发作,其中中风最为常见。处理主动脉夹层需要谨慎控制血压,以防止夹层进展,同时避免脑和脊髓灌注受损。颈动脉受累,尤其是夹层,会增加中风和短暂性脑缺血发作的风险。紧急手术干预虽然对于预防破裂或修复夹层至关重要,但存在围手术期神经血管并发症的风险。脑电图和经颅多普勒的使用有助于早期检测和监测神经血管事件。我们讨论了某些血压药物在急性主动脉夹层治疗中的利弊。涉及心血管外科医生、神经科医生和重症监护专家的多学科方法对于优化预后和降低风险至关重要。早期识别和处理神经血管并发症至关重要,还需要进一步研究以制定有针对性的预防和治疗策略。