Dai Suming, Wang Ping, Wang Sijia, Chen Hong, Cui Zhixin, Lu Wenhai, Zhou Ziyi, Zhang Nan, Wang Zhuo, Lin Tengfei, Song Yun, Liu Lishun, Huang Xiao, Chen Ping, Tang Genfu, Duan Yong, Zhang Hao, Wang Binyan, Yang Yan, Tian Zezhong
School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, China.
Shenzhen Luohu District Chronic Disease Prevention and Treatment Hospital, Shenzhen, China.
Front Nutr. 2025 Jan 23;11:1502139. doi: 10.3389/fnut.2024.1502139. eCollection 2024.
Existing epidemiological studies investigated the association between a single vitamin and hypertension. However, the potential relationship between the level of circulating multivitamins and blood pressure has not been explored. We aimed to investigate the association between multiple fat-soluble vitamin levels and blood pressure.
A total of 2052 participants with essential hypertension were sampled nationwide. The plasma concentrations of fat-soluble vitamins (A, E, D, and K) were assessed using liquid chromatography coupled with the mass spectrometry method. Participants were categorized into different co-exposure patterns using the unsupervised K-means clustering method. The multiple linear regression model was used for subsequent analyses.
Participants were classified into two co-exposure patterns of fat-soluble vitamins. The levels of vitamins were relatively low in pattern 1, compared to pattern 2. Participants in pattern 2 had no significantly different blood pressure levels compared to pattern 1. However, the plasma 25-hydroxyvitamin D (VD) levels were negatively associated with SBP (logarithmic 10 transformed) ( = -0.002, 95% CI: -0.004, 0); participants in the fourth -tocopherol quartile had mean SBP levels that were 1.02% (95% CI: 0.43, 1.61%) greater than those in the lowest quartile ( for trend <0.01). In addition, no significant relationships were found between plasma VA/VK concentrations and blood pressure.
Although no significant association between fat-soluble vitamin co-exposure patterns and blood pressure was found, further analyses could imply that plasma -tocopherol levels may offset the potential protective effect of plasma VD on blood pressure among hypertensive adults. This provided a novel perspective for exploring the joint effects of fat-soluble vitamins on blood pressure. Further studies are warranted to better understand the implications.
现有的流行病学研究调查了单一维生素与高血压之间的关联。然而，循环多种维生素水平与血压之间的潜在关系尚未得到探索。我们旨在研究多种脂溶性维生素水平与血压之间的关联。
在全国范围内对2052名原发性高血压患者进行了抽样。采用液相色谱-质谱联用法评估脂溶性维生素（A、E、D和K）的血浆浓度。使用无监督K均值聚类方法将参与者分为不同的共暴露模式。随后采用多元线性回归模型进行分析。
参与者被分为两种脂溶性维生素共暴露模式。与模式2相比，模式1中的维生素水平相对较低。模式2中的参与者与模式1相比，血压水平无显著差异。然而，血浆25-羟基维生素D（VD）水平与收缩压（对数转换为10）呈负相关（β = -0.002，95%CI：-0.004，0）；处于第四个生育酚四分位数的参与者的平均收缩压水平比最低四分位数的参与者高1.02%（95%CI：0.43，1.61%）（趋势检验P<0.01）。此外，未发现血浆视黄醇/维生素K浓度与血压之间存在显著关系。
虽然未发现脂溶性维生素共暴露模式与血压之间存在显著关联，但进一步分析可能意味着血浆生育酚水平可能抵消血浆VD对高血压成年人血压的潜在保护作用。这为探索脂溶性维生素对血压的联合作用提供了一个新的视角。有必要进行进一步研究以更好地理解其意义。
