Manenzhe Shumani Charlotte, Koutras Sandra, Zwane Nompumelelo Benedicta, Masilana Aubrey Isaac, Shangase Sindisiwe Londiwe
Department of Periodontics and Oral Medicine, University of Pretoria, Pretoria, South Africa.
Department of Oral Medicine and Periodontics, University of the Witwatersrand, Johannesburg, South Africa.
Front Dent Med. 2024 May 22;5:1408839. doi: 10.3389/fdmed.2024.1408839. eCollection 2024.
The extensive studies on show a positive association with periodontitis, demonstrating elevated levels compared to traditional periodontal pathogens in severe disease. Periodontitis is a chronic multifactorial disease induced by a dysbiotic microbiota in a susceptible host whilst diabetes is an established risk factor for periodontitis. Diabetes has been shown to alter the subgingival microbiota into distinct microbial communities which favours the shift towards disease. It is these very distinct subgingival microbiota that are believed to contribute to the high prevalence and severity of periodontitis in diabetic patients. This dysbiotic microbiota constitute traditional periodontal pathogens which include among others the red complex triad (), , the orange complex ( etc.) and other emerging pathogens such as that were previously unrecognised as role players in the pathogenesis of periodontitis. is an asaccharolytic anaerobic gram-positive rod (AAGPR) currently considered to be one of the potential drivers of periodontitis progression and worsening through its unique virulence characteristics. Various mechanisms through which contributes to the pathogenesis and severity of periodontitis have been reported. The mechanisms involved in the bidirectional relationship between periodontitis and diabetes are continuously being explored in order to enhance individualised preventative and management approaches in affected patients. This review aims to report on this emerging periodontal pathogen and its capacity to influence dysbiosis within a complex subgingival microbial community; including its potential role in the bidirectional relationship between diabetes and periodontitis. This review will highlight as a potential prognostic indicator for disease worsening, which will help improve management protocols for periodontitis and diabetes.
关于……的广泛研究表明其与牙周炎呈正相关，在严重疾病中，与传统牙周病原体相比，其水平升高。牙周炎是一种由易感宿主中微生物群落失调引起的慢性多因素疾病，而糖尿病是牙周炎的既定危险因素。糖尿病已被证明会将龈下微生物群改变为不同的微生物群落，这有利于向疾病转变。正是这些非常独特的龈下微生物群被认为导致了糖尿病患者牙周炎的高患病率和严重程度。这种失调的微生物群构成了传统的牙周病原体，其中包括红色复合体三联征（……）、……、橙色复合体（……等）以及其他新兴病原体，如……，这些病原体以前未被认为在牙周炎发病机制中起作用。……是一种不产糖的厌氧革兰氏阳性杆菌（AAGPR），目前被认为是通过其独特的毒力特征导致牙周炎进展和恶化的潜在驱动因素之一。已经报道了……导致牙周炎发病机制和严重程度的各种机制。为了加强对受影响患者的个体化预防和管理方法，正在不断探索牙周炎和糖尿病之间双向关系所涉及的机制。本综述旨在报告这种新兴的牙周病原体及其影响复杂龈下微生物群落中生态失调的能力；包括其在糖尿病和牙周炎双向关系中的潜在作用。本综述将强调……作为疾病恶化的潜在预后指标，这将有助于改善牙周炎和糖尿病的管理方案。
