This study aims to determine the effectiveness of combining pulsed dye laser (PDL) and ablative fractional carbon dioxide laser (AFCL) in the treatment of scars in pediatric patients, as well as to identify appropriate treatment parameters, initial treatment timing, and treatment intervals through a systematic literature review. A literature search was conducted between April 6, 2014 and April 6, 2024 in four databases to select studies on the effects of the combination of carbon dioxide fractional laser and pulsed dye laser therapy in children hypertrophic burn scars. This systematic literature review included 497 participants across 8 studies, with individual study sample sizes ranging from 17 to 125 participants. 7 studies reported the gender distribution of participants, with a higher proportion of males (60%, n = 264) than females (40%, n = 170). The average age of the patients was 7.18 years, and scald (62%, n = 235) were identified as the primary cause of scar. The combination therapy of 595 nm PDL and 10,600 nm AFCL significantly improved Vancouver Scar Scale (VSS) / Patient and Observer Scar Assessment Scale (POSAS) score. Study treatment intervals were approximately 1-2 months for simultaneous treatment and 1 month for PDL and 3 months for AFCL for sequential treatment. Two studies investigated the efficacy of early laser therapy (< 3 months), the AFCL laser energy parameters ranged from 30 mJ-50 mJ, significantly lower than the rest of the studies of laser energy parameters, which ranged from 50 mJ-120 mJ. The PDL energy density parameters showed little difference from study to study and were in the range of 5-12 J/cm. Complications after treatment (4%, n = 22), with rash being the most common (50%, n = 11). Rational use of PDL combined with AFCL (lower laser energy, increase density parameters, shorten treatment intervals (< 1 month)) can safely and effectively treat hypertrophic scars in pediatric burn patients and is superior to single-type laser therapy in efficacy. Significant disorganization was observed among studies suggesting the need to explore high-level evidence-based clinical research that may improve treatment outcomes.