Study of the mutagenic action of cyclophosphane on bacteria in host-mediated assay.

The mutagenic actin of cyclophosphane (CP) on the bacterium S. typhimurium TA 1950 in host-mediated assay (mice) was investigated. The mutagenic effect of CP depended on the dose. Administration of carbon tetrachloride (CCl4) to the animals modified the level of the mutagenic effect of CP. The direction of the modification depended on the time elapsed between the introduction of CCl4 and CP. The use of adrenalectomized animals as the mediator led to an increase in the frequency of mutations induced by CP in indicator bacteria.