用于多难治性类风湿关节炎的CD-19嵌合抗原受体T细胞 - Suppr

CD-19 CAR-T cells for polyrefractory rheumatoid arthritis.

作者信息

Lidar Merav, Rimar Doron, David Paula, Jacoby Elad, Shapira-Frommer Ronnie, Itzhaki Orit, Slobodin Gleb, Stern Myriam D, Eshed Iris, Sanalla Tamer, Marcus Ronit, Shimoni Avichai, Yerushalmi Ronit, Shem Tov Noga, Danylesko Ivetta, Avigdor Abraham

机构信息

Rheumatology Unit, Sheba Medical Center, Tel Hashomer, Tel Aviv, Israel; Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Tel Aviv, Israel.

Rheumatology Unit, Bnai-Zion Medical Center, Haifa, Israel; Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Haifa, Israel. Electronic address: https://twitter.com/

出版信息

Ann Rheum Dis. 2025 Feb;84(2):370-372. doi: 10.1136/ard-2024-226437. Epub 2025 Jan 2.

DOI:10.1136/ard-2024-226437

PMID:39919909

Abstract

摘要

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CD-19 CAR-T cells for polyrefractory rheumatoid arthritis.用于多难治性类风湿关节炎的CD-19嵌合抗原受体T细胞

Ann Rheum Dis. 2025 Feb;84(2):370-372. doi: 10.1136/ard-2024-226437. Epub 2025 Jan 2.

CD8 T Cells Expressing an HLA-DR1 Chimeric Antigen Receptor Target Autoimmune CD4 T Cells in an Antigen-Specific Manner and Inhibit the Development of Autoimmune Arthritis.CD8 T 细胞表达 HLA-DR1 嵌合抗原受体以抗原特异性方式靶向自身免疫性 CD4 T 细胞并抑制自身免疫性关节炎的发展。

J Immunol. 2022 Jan 1;208(1):16-26. doi: 10.4049/jimmunol.2100643. Epub 2021 Nov 24.

In vitro elimination of autoreactive B cells from rheumatoid arthritis patients by universal chimeric antigen receptor T cells.通过通用嵌合抗原受体 T 细胞从类风湿关节炎患者体内清除自身反应性 B 细胞。

Ann Rheum Dis. 2021 Feb;80(2):176-184. doi: 10.1136/annrheumdis-2020-217844. Epub 2020 Sep 30.

Clematichinenoside AR alleviates rheumatoid arthritis by inhibiting synovial angiogenesis through the HIF-1α/VEGFA/ANG2 axis.铁线莲苷AR通过HIF-1α/VEGFA/ANG2轴抑制滑膜血管生成来减轻类风湿性关节炎。

Phytomedicine. 2025 Apr;139:156552. doi: 10.1016/j.phymed.2025.156552. Epub 2025 Feb 21.

Review article: moving towards common therapeutic goals in Crohn's disease and rheumatoid arthritis.综述文章：迈向克罗恩病和类风湿关节炎的共同治疗目标

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Sustained drug-free remission in rheumatoid arthritis associated with diffuse large B-cell lymphoma following tandem CD20-CD19-directed non-cryopreserved CAR-T cell therapy using zamtocabtagene autoleucel.在使用 Zalmtocecabtagene Autoleucel 进行双靶向 CD20-CD19 非冷冻 CAR-T 细胞治疗后，类风湿关节炎患者伴弥漫性大 B 细胞淋巴瘤实现持续无药物缓解。

RMD Open. 2024 Oct 23;10(4):e004727. doi: 10.1136/rmdopen-2024-004727.

Safety and efficacy of CAR-T cell therapy in patients with autoimmune diseases: a systematic review.嵌合抗原受体T细胞疗法在自身免疫性疾病患者中的安全性和有效性：一项系统评价

Rheumatol Int. 2025 Jan 4;45(1):18. doi: 10.1007/s00296-024-05772-5.

T gamma delta cells in juvenile rheumatoid arthritis and rheumatoid arthritis. In the juvenile rheumatoid arthritis synovium the T gamma delta cells express activation antigens and are predominantly V delta 1+, and a significant proportion of these patients have elevated percentages of T gamma delta cells.青少年类风湿关节炎和类风湿关节炎中的Tγδ细胞。在青少年类风湿关节炎滑膜中，Tγδ细胞表达活化抗原，且主要为Vδ1+，并且这些患者中有相当一部分Tγδ细胞百分比升高。

Scand J Immunol. 1990 Dec;32(6):651-9. doi: 10.1111/j.1365-3083.1990.tb03207.x.

Is the C-reactive protein-to-albumin ratio the most remarkable simple inflammatory marker showing active disease in patients with axial spondyloarthritis, psoriatic arthritis, and rheumatoid arthritis?C 反应蛋白与白蛋白比值是反映中轴型脊柱关节炎、银屑病关节炎和类风湿关节炎患者疾病活动度最显著的简单炎症标志物吗？

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Serum C-Reactive Protein/Albumin Ratio in Rheumatoid Arthritis and its Relationship With Disease Activity, Physical Function, and Quality of Life.类风湿关节炎患者血清C反应蛋白与白蛋白比值及其与疾病活动度、身体功能和生活质量的关系

Arch Rheumatol. 2020 Feb 7;35(2):247-253. doi: 10.46497/ArchRheumatol.2020.7456. eCollection 2020 Jun.

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Research progress on chimeric antigen receptor-based immunotherapy against autoimmune diseases.基于嵌合抗原受体的自身免疫性疾病免疫治疗研究进展

Hum Vaccin Immunother. 2025 Dec;21(1):2538350. doi: 10.1080/21645515.2025.2538350. Epub 2025 Aug 1.

Immune mediated inflammatory diseases: moving from targeted biologic therapy, stem cell therapy to targeted cell therapy.免疫介导的炎症性疾病：从靶向生物疗法、干细胞疗法到靶向细胞疗法。

Front Immunol. 2025 Apr 7;16:1520063. doi: 10.3389/fimmu.2025.1520063. eCollection 2025.

Diverse potential of chimeric antigen receptor-engineered cell therapy: Beyond cancer.嵌合抗原受体工程细胞疗法的多样潜力：超越癌症。

Clin Transl Med. 2025 Apr;15(4):e70306. doi: 10.1002/ctm2.70306.

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CD-19 CAR-T cells for polyrefractory rheumatoid arthritis.

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