Hosokawa M, Satoh T, Ohkawara S, Ohmori S, Igarashi T, Ueno K, Kitagawa H
Res Commun Chem Pathol Pharmacol. 1985 Feb;47(2):285-8.
Hepatic microsomal carboxylesterase (E.C. 3.1.1.1) showed a different capacity for the hydrolysis of various substrates in rats. Adrenalectomy in castrated male rats slightly decreased the activities towards p-nitrophenyl-acetate and malathion. The magnitude of testosterone-induced changes in the hydrolase activities by liver microsomes in adrenalectomized-castrated male rats was markedly decreased castrated male rats. However, when 5 alpha-dihydrotestosterone was administered to adrenalectomized-castrated male rats, malathion and p-nitrophenylacetate hydrolase activities were significantly increased. But in all cases, isocarboxazid and acetanilide hydrolase activities were not affected by physiological states. These results suggest that hepatic microsomal carboxylesterases may be, at least in part, regulated by adrenal gland and gonadal hormones which exert different effects on the several isozymes of carboxylesterases.
肝微粒体羧酸酯酶（E.C. 3.1.1.1）在大鼠体内对各种底物的水解能力有所不同。去势雄性大鼠进行肾上腺切除后，对乙酸对硝基苯酯和马拉硫磷的活性略有降低。在去势-肾上腺切除雄性大鼠中，睾酮诱导的肝微粒体水解酶活性变化幅度在去势雄性大鼠中明显降低。然而，当对去势-肾上腺切除雄性大鼠给予5α-二氢睾酮时，马拉硫磷和乙酸对硝基苯酯水解酶活性显著增加。但在所有情况下，异卡波肼和乙酰苯胺水解酶活性不受生理状态影响。这些结果表明，肝微粒体羧酸酯酶可能至少部分受肾上腺和性腺激素调节，这些激素对羧酸酯酶的几种同工酶发挥不同作用。
