Berg J T, Smith R M
Res Commun Chem Pathol Pharmacol. 1985 Feb;47(2):309-12.
Endotoxin (1 mg/kg, I.P.) greatly reduces lung damage and pleural edema in rats exposed to greater than 99% oxygen. Endotoxin also activates and depletes complement in vitro. Prior in vivo complement depletion has been shown to protect rats from lung edema in some experimental models. This study was designed to evaluate the possibility that endotoxin may protect rats from oxygen toxicity by activating and thereby depleting complement. We found no significant changes in complement hemolytic activity in serum from endotoxin pretreated rats breathing greater than 99% oxygen at sea level for 60 hours. We also found that complement depletion prior to oxygen exposure failed to protect rats from the lung damage of oxygen toxicity. These results indicate that the mechanism of endotoxin protection from pulmonary oxygen toxicity does not involve complement.
内毒素（1毫克/千克，腹腔注射）可显著减轻暴露于99%以上氧气环境中的大鼠的肺损伤和胸膜水肿。内毒素在体外还能激活并消耗补体。先前的研究表明，在某些实验模型中，体内预先消耗补体可保护大鼠免受肺水肿的影响。本研究旨在评估内毒素是否可能通过激活并由此消耗补体来保护大鼠免受氧中毒。我们发现，在海平面呼吸99%以上氧气60小时的内毒素预处理大鼠的血清中，补体溶血活性没有显著变化。我们还发现，在氧气暴露前消耗补体并不能保护大鼠免受氧中毒导致的肺损伤。这些结果表明，内毒素保护免受肺部氧中毒的机制不涉及补体。
