Wan Tangjiang, Liang Yucheng, Wei Tianwen, Chen Zijie, Li Yafei
Department of Cardiology, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, 215000, Jiangsu Province, China.
Department of Cardiovascular Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
J Cardiovasc Transl Res. 2025 Apr;18(2):257-267. doi: 10.1007/s12265-025-10593-3. Epub 2025 Feb 7.
Ischemic heart disease (IHD), especially acute myocardial infarction (AMI), has a high mortality rate and poses a great threat to human health. When myocardial infarction occurs, the structure and function of the myocardium are significantly damaged, and its metabolisms switch from oxidative phosphorylation to glycolysis, producing lactate. Lactylation, as a newly discovered post-translational modification (PMT) in recent years, is involved in the regulation of gene expression, and cell proliferation. Emerging studies have revealed that lactate and lactylation modifications participate in inflammation and cardiac repair, and play an important role in cardiovascular diseases, such as myocardial infarction, myocardial fibrosis, and heart failure. Therefore, in this review, we discuss how glucose metabolism, glycolytic end-product lactate, and lactylation potentially interact with pathological processes, including inflammation, cardiac fibrosis, and heart failure. And targeting glycolysis and lactylation modification could provide a promising future for cardiovascular diseases.
缺血性心脏病（IHD），尤其是急性心肌梗死（AMI），死亡率很高，对人类健康构成巨大威胁。当心肌梗死发生时，心肌的结构和功能会受到显著损害，其代谢从氧化磷酸化转变为糖酵解，产生乳酸。乳酸化作为近年来新发现的一种翻译后修饰（PTM），参与基因表达调控和细胞增殖。新兴研究表明，乳酸和乳酸化修饰参与炎症反应和心脏修复，在心肌梗死、心肌纤维化和心力衰竭等心血管疾病中发挥重要作用。因此，在本综述中，我们讨论了糖代谢、糖酵解终产物乳酸和乳酸化如何可能与包括炎症、心脏纤维化和心力衰竭在内的病理过程相互作用。针对糖酵解和乳酸化修饰可能为心血管疾病带来光明的前景。
