Shi Ke, Huang Li-De, Li Dan, Luo Wei-Min, Liu Hua-Song, Ding Dong-Xiao, Guo Qiang, Liu Yue-Feng
Department of Thoracic Surgery, Beilun District People's Hospital of Ningbo, Ningbo City, China.
Department of Pain management, People's Hospital of Shiyan City, Hubei Medical University, Shiyan City, China.
BMC Gastroenterol. 2025 Feb 7;25(1):63. doi: 10.1186/s12876-025-03621-8.
Small nucleolar RNA host gene (SNHG) family were reported involved in various biological processes and may be used as a promising prognostic marker in esophageal cancer (EC). A meta-analysis was performed to investigate the relationship between SNHG expression and prognosis of EC in this study.
Relevant databases were browsed to obtain suitable publications. Hazard ratio (HR) with 95% confidence interval (CI) were extracted to explore the association between SNHG expression and EC prognosis. Odds ratio (OR) with 95%CI were extracted to assess the association between SNHG expression and other clinicopathological parameters. Sensitivity analysis and publication bias were performed to explore the reliability and robustness of the results. Bio-informatics has been explored in order to confirm our conclusions more comprehensively.
16 studies comprising 1229 patients were enrolled. The results showed that increasing SNHG expression indicated worse overall survival (HR: 1.392, 95%CI = 0.876-1.908). SNHG2, SNHG5, and SNHG12 were down-regulated, while other SNHGs were up-regulated in EC. In populations with low expression of SNHG2, SNHG5, and SNHG12, increasing SNHG expression predicted a favorable cancer prognosis (HR: 0.511, 95%CI = 0.322-0.700). Conversely, in populations with high expression of other SNHGs, SNHG expression indicated poor prognosis (OR: 2.340, 95%CI = 1.744-2.936). Elevated SNHG expression also implied advanced TNM stage (OR 1.578, 95%CI = 1.273-1.956) and lymph node metastasis (OR: 1.533, 95%CI = 1.205-1.950).
Increased expression of SNHG2, SNHG5, and SNHG12, and decreased expression of other SNHGs tended to have a favorable prognosis in patients with EC. These findings suggest that SNHG may serve as a prognostic marker and therapeutic target for EC.
据报道，小核仁RNA宿主基因（SNHG）家族参与多种生物学过程，可能作为食管癌（EC）有前景的预后标志物。本研究进行了一项荟萃分析，以探讨SNHG表达与EC预后之间的关系。
浏览相关数据库以获取合适的出版物。提取95%置信区间（CI）的风险比（HR），以探讨SNHG表达与EC预后之间的关联。提取95%CI的比值比（OR），以评估SNHG表达与其他临床病理参数之间的关联。进行敏感性分析和发表偏倚分析，以探讨结果的可靠性和稳健性。还进行了生物信息学分析，以更全面地证实我们的结论。
纳入了16项研究，共1229例患者。结果显示，SNHG表达增加表明总生存期较差（HR：1.392，95%CI = 0.876 - 1.908）。SNHG2、SNHG5和SNHG12在EC中表达下调，而其他SNHG表达上调。在SNHG2、SNHG5和SNHG12低表达人群中，SNHG表达增加预示着良好的癌症预后（HR：0.511，95%CI = 0.322 - 0.700）。相反，在其他SNHG高表达人群中，SNHG表达提示预后不良（OR：2.340，95%CI = 1.744 - 2.936）。SNHG表达升高还意味着TNM分期较晚（OR 1.578，95%CI = 1.273 - 1.956）和淋巴结转移（OR：1.533，95%CI = 1.205 - 1.950）。
SNHG2、SNHG5和SNHG12表达增加，其他SNHG表达减少，在EC患者中往往预后良好。这些发现表明，SNHG可能作为EC的预后标志物和治疗靶点。
