Ma Li, Gao Jin, Zhang Niu, Wang Jiawei, Xu Tianwei, Lei Tianyao, Zou Xiaoteng, Wei Chenchen, Wang Zhaoxia
Cancer Medical Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210011, Jiangsu, China.
Department of General Surgery, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210011, Jiangsu, China.
Cancer Cell Int. 2022 Mar 5;22(1):104. doi: 10.1186/s12935-022-02529-7.
Many studies in recent years have found that dysregulation of long non-coding RNAs (lncRNAs) can contribute to disease. Small nucleolar RNA host gene 17 (SNHG17) is a novel cancer-related lncRNA of the SNHG family which is highly expressed in various tumors and may exert oncogenic functions. Several studies have demonstrated that SNHG17 is closely related to the proliferation, migration, invasion, apoptosis, and chemical drug resistance of tumor cells, and clinical studies have found an association between high SNHG17 expression and poor prognosis. In this review, we summarize relevant studies investigating SNHG17, focusing on its biological function as well as its potential value for clinical applications.
近年来的许多研究发现，长链非编码RNA（lncRNA）的失调可导致疾病。小核仁RNA宿主基因17（SNHG17）是SNHG家族中一种新型的癌症相关lncRNA，在各种肿瘤中高度表达，并可能发挥致癌功能。多项研究表明，SNHG17与肿瘤细胞的增殖、迁移、侵袭、凋亡及化学耐药性密切相关，临床研究发现SNHG17高表达与预后不良有关。在这篇综述中，我们总结了有关SNHG17的相关研究，重点关注其生物学功能及其临床应用的潜在价值。
