Kong Linghan, Jin Wei, Jiang Yue, Yan Fuhua, Liu Jun, Leuthardt Eric C, Yang Guang-Zhong, Feng Yuan
School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200230, China; Institute of Medical Robotics, Shanghai Jiao Tong University, Shanghai 200240, China; National Engineering Research Center of Advanced Magnetic Resonance Technologies for Diagnosis and Therapy (NERC-AMRT), Shanghai Jiao Tong University, Shanghai 200240, China.
Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Neuroimage. 2025 Mar;308:121074. doi: 10.1016/j.neuroimage.2025.121074. Epub 2025 Feb 5.
Neuroscience advances have highlighted the potential of non-invasive brain stimulation in influencing cognitive and emotional processes. Conventional stimulation methods such as electrical, magnetic, and ultrasound have been studied intensively, but little is known about the mechanical stimulation.
To investigate the effects of 40 Hz transcranial vibration stimulation (TVS) on human brain activity, specifically focusing on changes in the Amplitude of Low-Frequency Fluctuation (ALFF), fractional ALFF (fALFF) and Regional Homogeneity (ReHo) as measures of spontaneous brain activity. Additionally, this study investigates alterations in the global blood-oxygen-level-dependent (gBOLD) signal and cerebrospinal fluid (CSF) inflow coupling, which serve as indicators of glymphatic system function.
A custom-built head actuator was used to apply 40 Hz TVS to human brain. Functional magnetic resonance imaging (fMRI) were performed before and after 5 mins TVS to explore the changes in ALFF and fALFF and the coupling of global brain activity with cerebrospinal fluid flow (CSF), which is related to the glymphatic clearance.
Significant increases were observed in both ALFF and fALFF metrics, indicating that 40 Hz TVS effectively enhanced spontaneous brain activity. Additionally, 40 Hz TVS promoted the synchronization of overall brain activity with CSF, suggesting an improvement in glymphatic clearance processes, an effect that 30 Hz or 50 Hz TVS did not replicate.
Non-invasive brain stimulation using TVS provided important implications for modulating brain physiology and showed prospective therapeutic benefits for neurological diseases.
神经科学的进展凸显了非侵入性脑刺激在影响认知和情感过程方面的潜力。传统的刺激方法，如电刺激、磁刺激和超声刺激，已经得到了深入研究，但对于机械刺激却知之甚少。
研究40赫兹经颅振动刺激（TVS）对人脑活动的影响，特别关注低频波动幅度（ALFF）、分数ALFF（fALFF）和局部一致性（ReHo）的变化，这些指标可作为自发脑活动的衡量标准。此外，本研究还调查了全脑血氧水平依赖（gBOLD）信号和脑脊液（CSF）流入耦合的变化，这些变化可作为类淋巴系统功能的指标。
使用定制的头部致动器对人脑施加40赫兹的TVS。在TVS 5分钟前后进行功能磁共振成像（fMRI），以探索ALFF和fALFF的变化，以及全脑活动与脑脊液流动（CSF）的耦合，这与类淋巴清除有关。
ALFF和fALFF指标均显著增加，表明40赫兹的TVS有效增强了自发脑活动。此外，40赫兹的TVS促进了全脑活动与CSF的同步，表明类淋巴清除过程有所改善，而30赫兹或50赫兹的TVS则没有重复这种效果。
使用TVS进行非侵入性脑刺激为调节脑生理学提供了重要启示，并显示出对神经系统疾病的潜在治疗益处。
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