Han Feng, Lee JiaQie, Chen Xi, Ziontz Jacob, Ward Tyler, Landau Susan M, Baker Suzanne L, Harrison Theresa M, Jagust William J
Department of Neuroscience, University of California, Berkeley, California, USA.
Department of Cellular and Tissue Imaging, Lawrence Berkeley National Laboratory, Berkeley, California, USA.
Alzheimers Dement. 2024 Dec;20(12):8541-8555. doi: 10.1002/alz.14296. Epub 2024 Nov 7.
Factors responsible for the deposition of pathological tau in the brain are incompletely understood. This study links macroscale tau deposition in the human brain to cerebrospinal fluid (CSF) flow dynamics using resting-state functional magnetic resonance imaging (rsfMRI).
Low-frequency (< 0.1 Hz) resting-state global brain activity is coupled with CSF flow and potentially reflects CSF dynamics-related clearance. We examined the correlation between rsfMRI measures of CSF inflow and global activity (gBOLD-CSF coupling) as a predictor, interacting with amyloid beta (Aβ), of tau and cortical thickness (dependent variables) across Alzheimer's Disease Neuroimaging Initiative (ADNI) participants from cognitively unimpaired through mild cognitive impairment (MCI) and Alzheimer's disease (AD).
Tau deposition in Aβ+ participants, accompanied by cortical thinning and cognitive decline, is associated with decreased gBOLD-CSF coupling. Tau mediates the relationship between coupling and thickness.
Findings suggest that resting-state global brain activity and CSF movements comodulate Alzheimer's tau deposition, presumably related to CSF clearance.
A non-invasive functional magnetic resonance imaging (fMRI) assessment of a CSF clearance-related process is carried out. Global brain activity is coupled with CSF inflow in human fMRI during resting state. Global fMRI-CSF coupling is correlated with tau in Alzheimer's disease (AD). This coupling measure is also associated with cortical thickness, mediated by tau.
导致病理性tau蛋白在大脑中沉积的因素尚未完全明确。本研究利用静息态功能磁共振成像（rsfMRI）将人类大脑中的宏观tau蛋白沉积与脑脊液（CSF）流动动力学联系起来。
低频（<0.1Hz）静息态全脑活动与脑脊液流动相关联，并可能反映与脑脊液动力学相关的清除过程。我们在阿尔茨海默病神经影像倡议（ADNI）的参与者中，研究了作为预测因子的rsfMRI脑脊液流入测量值与全脑活动（gBOLD-CSF耦合）之间的相关性，该耦合与淀粉样β蛋白（Aβ）相互作用，以tau蛋白和皮质厚度作为因变量，参与者涵盖了从认知未受损到轻度认知障碍（MCI）以及阿尔茨海默病（AD）的各个阶段。
Aβ阳性参与者的tau蛋白沉积，伴有皮质变薄和认知衰退，与gBOLD-CSF耦合降低有关。Tau蛋白介导了耦合与厚度之间的关系。
研究结果表明，静息态全脑活动和脑脊液运动共同调节阿尔茨海默病的tau蛋白沉积，这可能与脑脊液清除有关。
对与脑脊液清除相关的过程进行了非侵入性功能磁共振成像（fMRI）评估。在静息状态下，人类fMRI中的全脑活动与脑脊液流入相关联。全脑fMRI-CSF耦合与阿尔茨海默病（AD）中的tau蛋白相关。这种耦合测量也与皮质厚度相关，由tau蛋白介导。
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