Marais C
Rev Fr Gynecol Obstet. 1985 Feb 28;80(3):156-62.
The treatment of menopause comprises two phases: on the one hand, the curative treatment of the premature climateric syndrome, including a case by case discussion of the value of a hormonal or non-hormonal treatment; on the other hand, the preventive treatment of delayed deficiency, for which only opotherapy, using estrogens and progestatives, is indicated. The therapeutic choice is guided, in the first case, by the existence or non-existence of an objective counter-indication to the use of estrogens or of reticence on the part of the patient to the use of a hormonal treatment. In the second case, the decision is based only on the benefit/risk ratio, and estrogeno-therapy, in the opinion of many, should be reserved for women in whom estrogen deficiency has been demonstrated. Veralipride (Agreal) is, medically speaking, a non-hormonal drug, and has a proven efficacy in vasomotor heat flushes and the psychofunctional signs of confirmed menopause. It is well tolerated and is easy to use.
一方面是对早发性更年期综合征的治疗,包括逐案讨论激素或非激素治疗的价值;另一方面是对延迟性缺乏症的预防性治疗,对此仅需采用使用雌激素和孕激素的替代疗法。在第一种情况下,治疗选择取决于是否存在使用雌激素的客观禁忌证,或者患者是否不愿接受激素治疗。在第二种情况下,决策仅基于获益/风险比,并且在许多人看来,雌激素疗法应仅保留给已证实存在雌激素缺乏的女性。从医学角度讲,维拉唑酮(阿格列)是一种非激素类药物,已证实其对血管舒缩性潮热以及确诊更年期的心理功能症状有效。它耐受性良好且易于使用。