Uzan S, Salat-Baroux J
Rev Fr Gynecol Obstet. 1986 Sep 1;81(8):407-12.
Considered for a long time as an unavoidable phenomenon secondary to a sudden reduction in hormones, the vaso-motor flushes of menopause have generated, these past few years, a renewal of interest for two reasons: 1) A better knowledge of the etiological mechanisms and experimental and therapeutic observations lead to believe at the present time that their origin is at a central level (hypothalamus) with upsetting of the balance of the cerebral neuro-transmitters; this upsetting seems to be the common mechanism of occurrence of the sudden flushes and the hormonal disorders observed during this phenomenon. 2) The possibility to use (beside the classical hormonal means) non hormonal products, especially Veralipride, which acts directly at the level of the cerebral neuro-transmitters.
长期以来,绝经后的血管舒缩性潮红一直被视为激素突然减少引发的不可避免的现象。然而在过去几年里,人们对它的兴趣再度燃起,原因有二:1)对病因机制、实验及治疗观察的更深入了解使人们目前认为其起源于中枢层面(下丘脑),伴有脑神经递质平衡失调;这种失调似乎是该现象中突发潮红及激素紊乱发生的共同机制。2)(除了传统的激素手段外)有可能使用非激素产品,尤其是维拉必利,它直接作用于脑神经递质水平。