Einarsson K, Angelin B, Glaumann H
Scand J Gastroenterol. 1985 Mar;20(2):175-8. doi: 10.3109/00365528509089652.
The present study was undertaken to evaluate the clinical usefulness of determining the plasma disappearance of 14C-glycocholic acid in the diagnosis of hepatic disease. This test was compared with the sulfobromophthalein test in 8 control subjects and 46 patients with abnormal liver histology (15 with fatty liver, 20 with alcoholic liver cirrhosis, 6 with primary biliary cirrhosis, and 5 with chronic hepatitis). The best distinction between controls and patients with liver disease was obtained by using the ratio between the plasma radioactivities at 45 and 2 min. However, even then, the 14C-glycocholic acid test had a very low sensitivity for the four groups of patients (0, 60, 50, and 40%, respectively) compared with the sulfobromophthalein test (73%, 90%, 67%, and 100% respectively). The lower sensitivity of the 14C-glycocholic acid test may be explained by the assumption that the clearance of a radioactive tracer dose is more dependent on liver blood flow than on liver function. This test is thus of little clinical value in separating patients with and without normal hepatic histology.
本研究旨在评估测定14C-甘氨胆酸血浆消失率在肝病诊断中的临床实用性。在8名对照受试者和46例肝组织学异常患者（15例脂肪肝、20例酒精性肝硬化、6例原发性胆汁性肝硬化和5例慢性肝炎）中，将该试验与磺溴酞钠试验进行了比较。通过使用45分钟和2分钟时的血浆放射性比值，可实现对照者与肝病患者之间的最佳区分。然而，即便如此，与磺溴酞钠试验（分别为73%、90%、67%和100%）相比，14C-甘氨胆酸试验对这四组患者的敏感性非常低（分别为0、60%、50%和40%）。14C-甘氨胆酸试验较低的敏感性可能是由于放射性示踪剂剂量的清除更多地依赖于肝血流量而非肝功能这一假设。因此，该试验在区分肝组织学正常和异常的患者方面几乎没有临床价值。
