Kyösola K, Penttilä O, Ihamäki T, Varis K, Salaspuro M
Scand J Gastroenterol. 1985 Mar;20(2):254-6. doi: 10.3109/00365528509089667.
Liver biopsy specimens from 34 consecutive patients undergoing laparoscopy were processed for glyoxylic acid-induced fluorescence histochemical analysis. Most of the adrenergic nerves were located in the interlobular spaces and confined to blood vessels; no direct functional adrenergic innervation of the hepatocytes could be demonstrated. In eight cases of intrahepatic cholestasis, however, fluorescing varicose adrenergic axons were observed in patchy areas of accumulations of bile pigments. Otherwise the results were analogous in histologically normal liver tissue and in liver disease regardless of the underlying pathology. Methodological difficulties may explain some earlier contradictory results.
对34例连续接受腹腔镜检查的患者的肝活检标本进行了乙醛酸诱导荧光组织化学分析。大多数肾上腺素能神经位于小叶间隙并局限于血管；未发现对肝细胞有直接功能性肾上腺素能神经支配。然而，在8例肝内胆汁淤积病例中，在胆汁色素积聚的斑片状区域观察到有荧光的曲张肾上腺素能轴突。在组织学正常的肝组织和肝病中，无论潜在病理情况如何，结果都是类似的。方法学上的困难可能解释了一些早期相互矛盾的结果。
