Waris T, Kaarela O, Lasanen L, Junila J, Ruuskanen M, Kyösola K
Department of Surgery, Oulu University Central Hospital, Finland.
J Surg Res. 1991 Oct;51(4):303-9. doi: 10.1016/0022-4804(91)90112-y.
It has been claimed earlier that perivascular sympathectomy removes distal adrenergic innervation of the vessels. Based on preliminary results suggesting the contrary, the purpose of this work was to reconsider the denervation effect of perivascular sympathectomy. We operated on 40 rats using different denervation methods mainly to test the effects of perivascular sympathectomy on the distal saphenous vessels of the leg. The operations were performed on the right leg, while the left leg was used as a control. Samples were taken 2 days after the operations for glyoxylic acid-induced fluorescence examination for the histochemical demonstration of adrenergic nerves. Perivascular sympathectomy seemed to remove the adrenergic innervation only from the operated segment of the vessel. There was a short segment of diminished innervation a few millimeters in length just distal to the perivascular sympathectomy while the more distal adrenergic nerves around the vessels appeared to be normal. When the saphenous nerve was cut the adrenergic innervation seemed to disappear for 1 cm and to continue to be diminished at the medial malleolus site. Lumbar sympathectomy did not seem to remove the distal adrenergic nerves around the vessels, but caused only a slight decrease in innervation. It can be concluded that the peripheral adrenergic innervation is apparently normal after perivascular sympathectomy and that the operation does not have the previously assumed denervation effects.
此前有人声称，血管周围交感神经切除术可去除血管的远端肾上腺素能神经支配。基于初步结果显示情况相反，这项工作的目的是重新考虑血管周围交感神经切除术的去神经效应。我们对40只大鼠采用不同的去神经方法进行手术，主要是为了测试血管周围交感神经切除术对腿部隐静脉远端血管的影响。手术在右腿进行，左腿用作对照。术后2天取样，进行乙醛酸诱导荧光检查，以进行肾上腺素能神经的组织化学显示。血管周围交感神经切除术似乎仅从手术部位的血管去除了肾上腺素能神经支配。在血管周围交感神经切除术远端几毫米处有一小段神经支配减少，而血管周围更远端处的肾上腺素能神经似乎正常。切断隐神经时，肾上腺素能神经支配似乎在1厘米范围内消失，在内踝部位仍持续减少。腰交感神经切除术似乎并未去除血管周围的远端肾上腺素能神经，只是导致神经支配略有减少。可以得出结论，血管周围交感神经切除术后外周肾上腺素能神经支配显然正常，且该手术没有之前所认为的去神经效应。
