Alipour Fateme, Abdi Parisa, Asadigandomani Hassan, Khodaparast Mehdi, Montazeriani Zahra, Sajedi Marzieh
Translational Ophthalmology Research Center (TORC), Farabi Eye Hospital, Tehran University of Medical Sciences, South Kargar Street, Qazvin Square, Qazvin Street, Box: 14176-13151, Tehran, Iran.
Department of Medical Physics and Biomedical Engineering, Advanced Medical Technologies and Equipment Institute (AMTEI), Tehran University of Medical Sciences, Tehran, Iran.
Sci Rep. 2025 Feb 8;15(1):4759. doi: 10.1038/s41598-025-89159-x.
This study aimed to compare the outcomes of Optical Coherence Tomography-Angiography (OCT-A) with the clinical assessments conducted by an experienced ophthalmologist, as well as to analyze the alterations in the conjunctiva of individuals utilizing spherical scleral contact lenses. OCT-A imaging was conducted on 13 patients (mean age: 34.1 years, 10 males) in a prospective study at two time points: at least 8 h post-lens removal and 1-hour post-lens application. The scleral region in the quadrants (superior, inferior, temporal, and nasal) was designated as the region of interest (ROI), located 3 mm from the limbus. This ROI was further divided into two bands: Band 1 (1.5 mm width under the lens) and Band 2 (1.5 mm width outside the lens). The vascular density ratios in the inferior quadrant were significantly reduced after the lens fitting: ROI (0.362 ± 0.074 post-lens vs. 0.452 ± 0.099 pre-lens, adjusted P-value = 0.027) and Band 1 (0.353 ± 0.075 post-lens vs. 0.462 ± 0.095 pre-lens, adjusted P-value = 0.008). In the superior (P-value = 0.026), inferior (P-value < 0.001), and temporal (P-value < 0.001) quadrants, the degree of conjunctival impingement, as scored by an experienced ophthalmologist using slit photographs, was significantly correlated with OCT-A findings. In conclusion, OCT-A identifies microvascular changes undetectable by slit-lamp examination, providing quantitative insights into vascular alterations from scleral lens use and complementing clinical evaluations.
本研究旨在比较光学相干断层扫描血管造影（OCT-A）与经验丰富的眼科医生进行的临床评估结果，并分析使用球面巩膜接触镜的个体结膜的变化。在一项前瞻性研究中，对13名患者（平均年龄：34.1岁，10名男性）在两个时间点进行了OCT-A成像：摘镜后至少8小时和戴镜后1小时。将象限（上、下、颞、鼻）中的巩膜区域指定为感兴趣区域（ROI），距角膜缘3mm。该ROI进一步分为两个带：带1（镜片下方1.5mm宽）和带2（镜片外侧1.5mm宽）。戴镜后下象限的血管密度比显著降低：ROI（戴镜后0.362±0.074，戴镜前0.452±0.099，调整后P值=0.027）和带1（戴镜后0.353±0.075，戴镜前0.462±0.095，调整后P值=0.008）。在上方（P值=0.026）、下方（P值<0.001）和颞侧（P值<0.001）象限，经验丰富的眼科医生使用裂隙照片评分的结膜受压程度与OCT-A结果显著相关。总之，OCT-A可识别裂隙灯检查无法检测到的微血管变化，为巩膜镜使用引起的血管改变提供定量见解，并补充临床评估。
