Department of Ophthalmology and Visual Sciences (S.T., C.J.R., A.M., S.P., C.M.), The Ohio State University, Columbus, OH; and Department of Biomedical Engineering (C.J.R., A.M.), The Ohio State University, Columbus, OH.
Eye Contact Lens. 2022 Nov 1;48(11):466-470. doi: 10.1097/ICL.0000000000000937. Epub 2022 Sep 8.
To assess scleral lens fluid reservoir (FR) change simultaneously in four quadrants with single acquisition using novel ANTERION anterior segment swept-source optical coherence tomography (SS-OCT).
A prospective, observational, clinical study of 18 subjects (30 eyes) was performed on adults fitted with a scleral lens for ocular surface disease (n=8), irregular cornea/scar (n=7), and corneal ectasia (n=15). ANTERION anterior segment SS-OCT imaging was obtained at the initial visit and at the follow-up to determine pre and post scleral lens settling, measured in microns, centrally and peripherally. Peripheral measurements were grouped into four quadrants. Repeated-measures ANOVA was performed comparing vault post minus pre differences by quadrant, and TTests comparing difference in FR by lens design were performed with a significant threshold at P <0.05.
The mean central scleral lens settling was significant at -48.3±41.7 μm. The change in FR by quadrant was superior (S): -47.8±67.3 μm, inferior (I): -68.0±102.2 μm, nasal (N) -46.3±63.4 μm, and temporal (T): -56.7±49.3 μm. There were no significant differences in lens settling between the quadrants. Within the three categories, the irregular cornea group experienced significantly greater lens settling. There was no significant difference in central FR when comparing lens design or lens diameter.
The ANTERION SS-OCT allows for high-resolution central and peripheral assessment of FR in scleral lens wear. With increased technology available for scleral lens customization, this imaging modality can assist in more detailed assessment in quadrant-specific scleral lens designs.
使用新型 ANTERION 眼前节扫频源光学相干断层扫描（SS-OCT）单次采集评估四个象限中的巩膜镜片液腔（FR）变化。
对佩戴巩膜镜片治疗眼表疾病（n=8）、不规则角膜/瘢痕（n=7）和角膜扩张症（n=15）的成年人进行了一项前瞻性、观察性、临床研究。在初次就诊和随访时使用 ANTERION 眼前节 SS-OCT 成像来确定中央和周边的巩膜镜片沉降前后的变化，以微米为单位进行测量。周边测量分为四个象限。采用重复测量方差分析比较穹顶后减去前的差异按象限，采用 T 检验比较不同镜片设计的 FR 差异，以 P<0.05 为显著阈值。
中央巩膜镜片沉降的平均值为-48.3±41.7μm。通过象限的 FR 变化分别为：上象限（S）-47.8±67.3μm，下象限（I）-68.0±102.2μm，鼻侧（N）-46.3±63.4μm和颞侧（T）-56.7±49.3μm。象限之间的镜片沉降没有显著差异。在三个类别中，不规则角膜组的镜片沉降显著更大。比较镜片设计或镜片直径时，中央 FR 无显著差异。
ANTERION SS-OCT 允许对巩膜镜片佩戴者的 FR 进行高分辨率的中央和周边评估。随着巩膜镜片定制化的技术不断进步，这种成像方式可以帮助对象限特定的巩膜镜片设计进行更详细的评估。
