Tabar Mohsen Shaygan, Nilghaz Maryam, Hekmatdoost Azita, Pashayee-Khamene Fereshteh, Mokhtari Zeinab, Karimi Sara, Ahmadzadeh Saleheh, Saberifiroozi Mehdi, Hatami Behzad, Yari Zahra
Student Research Committee, Department of Clinical Nutrition and dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Clinical Nutrition and dietetics Department, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Sci Rep. 2025 Feb 8;15(1):4798. doi: 10.1038/s41598-025-89433-y.
The role of diet in reducing the burden of liver disease and mortality attributed to cirrhosis is very imperative. The present study scrutinized the relationship between dietary advanced glycation end products (AGEs) and mortality in patients with cirrhosis. This research was a prospective cohort study on 166 ambulatory cirrhotic patients who had been diagnosed with cirrhosis for a maximum of six months. Follow-up of patients continued for 5 years until May 2024. To determine the incidence of mortality in the quartiles of dietary AGEs, cox regression models were used with the adjustment of potential confounding variables. Although the first model of the analysis by adjusting the results for age and sex failed to show a significant increase in the risk of mortality in patients (HR = 2.64; 95% CI = 0.9-7.5, P trend = 0.075), after adjusting the results for further confounders in the second (HR = 3.56; 95% CI = 1.1-11.6, P trend = 0.040) and third (HR = 3.3; 95% CI = 1.79-13.7, P trend = 0.048) models, the P trend for the risk of mortality during the quartiles of AGEs became significant. In addition, along with increasing trend of dietary AGEs, the number of deaths increased significantly (P = 0.024). Higher mortality risk was generally attributed to higher dietary AGEs in patients with cirrhosis.
饮食在减轻肝病负担及降低肝硬化所致死亡率方面的作用至关重要。本研究仔细审查了饮食晚期糖基化终产物（AGEs）与肝硬化患者死亡率之间的关系。这项研究是一项前瞻性队列研究，对象为166名门诊肝硬化患者，他们被诊断为肝硬化的时间最长为6个月。对患者的随访持续了5年，直至2024年5月。为了确定饮食AGEs四分位数中的死亡率发生率，使用了Cox回归模型，并对潜在的混杂变量进行了调整。尽管在按年龄和性别调整结果后的第一个分析模型中，未显示患者死亡率风险有显著增加（HR = 2.64；95% CI = 0.9 - 7.5，P趋势 = 0.075），但在第二个（HR = 3.56；95% CI = 1.1 - 11.6，P趋势 = 0.040）和第三个（HR = 3.3；95% CI = 1.79 - 13.7，P趋势 = 0.048）模型中对结果进行进一步混杂因素调整后，AGEs四分位数期间死亡率风险的P趋势变得显著。此外，随着饮食AGEs的增加趋势，死亡人数显著增加（P = 0.024）。肝硬化患者较高的死亡率风险通常归因于较高的饮食AGEs。
