Hwang Sungjun, Kim Jae Hyun, Park Sae-Jin, Yu Su Jong, Kim Yoon Jun, Yoon Jung-Hwan, Lee Jeong Min
Department of Radiology, Inje University Ilsan Paik Hospital, Goyang, Korea.
Department of Radiology, Seoul National University Hospital, Seoul, Korea.
J Liver Cancer. 2025 Mar;25(1):91-98. doi: 10.17998/jlc.2025.01.25. Epub 2025 Feb 7.
BACKGROUNDS/AIMS: Radiofrequency ablation (RFA) is widely employed for managing recurrent hepatocellular carcinoma (HCC) following transarterial chemoembolization (TACE). However, local tumor progression (LTP) after treatment remains a significant challenge. This study evaluates the efficacy of saline-perfused bipolar RFA using twin internally cooled-perfusion (TICP) electrodes in managing recurrent HCC post-TACE.
Between September 2017 and January 2019, 100 patients with 105 nodules (mean diameter, 1.6±0.5 cm) were prospectively enrolled. Bipolar RFA with TICP electrodes was performed under ultrasound-computed tomography/magnetic resonance fusion guidance. The primary outcome was the 2-year cumulative incidence of LTP.
The technical success and technique efficacy rates were 100% and 97%, respectively. During a median follow-up period of 34.0 months (range, 3-41), the estimated LTP rates were 13.3% at 1 year and 17.7% at 2 years. Progression-free survival rates were 37.8% and 27.7% at 1 year and 2 years, respectively.
Saline-perfused bipolar RFA using TICP electrodes demonstrates promising results for recurrent HCC after TACE, achieving high technical success and effective local tumor control rates.
背景/目的：射频消融术（RFA）被广泛应用于经动脉化疗栓塞术（TACE）后复发性肝细胞癌（HCC）的治疗。然而，治疗后的局部肿瘤进展（LTP）仍然是一个重大挑战。本研究评估了使用双极内部冷却灌注（TICP）电极的盐水灌注双极RFA治疗TACE后复发性HCC的疗效。
2017年9月至2019年1月，前瞻性纳入100例患者共105个结节（平均直径1.6±0.5 cm）。在超声-计算机断层扫描/磁共振融合引导下使用TICP电极进行双极RFA。主要结局是LTP的2年累积发生率。
技术成功率和技术有效率分别为100%和97%。在中位随访期34.0个月（范围3 - 41个月）内，1年和2年的LTP估计发生率分别为13.3%和17.7%。1年和2年的无进展生存率分别为37.8%和27.7%。
使用TICP电极的盐水灌注双极RFA在治疗TACE后的复发性HCC方面显示出有前景的结果，实现了高技术成功率和有效的局部肿瘤控制率。
