Douglas Abby P, Lamoth Frederic, John Teny M, Groll Andreas H, Shigle Terri Lynn, Papanicolaou Genovefa A, Chemaly Roy F, Carpenter Paul A, Dadwal Sanjeet S, Walsh Thomas J, Kontoyiannis Dimitrios P
Department of Infectious Diseases, National Centre for Infections in Cancer, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia; Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, Victoria, Australia.
Infectious Diseases Service and Institute of Microbiology, University Hospital of Lausanne and Lausanne University, Lausanne, Switzerland.
Transplant Cell Ther. 2025 Apr;31(4):194-223. doi: 10.1016/j.jtct.2025.01.892. Epub 2025 Feb 7.
The Practice Guidelines Committee of the American Society of Transplantation and Cellular Therapy partnered with its Transplant Infectious Disease Special Interest Group to create a guideline focusing on non-Aspergillus invasive molds, which are uncommon yet lethal invasive fungal diseases in the peri-hematopoietic cell transplant (HCT) period. We used a compendium-style approach by dissecting this broad, heterogeneous, and highly complex topic into a series of standalone frequently asked questions (FAQs) and tables. Adult and pediatric infectious diseases and HCT content experts developed, then answered FAQs, and finalized topics with harmonized recommendations. All the evidence for non-Aspergillus invasive mold infection is non-RCT and mostly level III, therefore there are no recommendation grades, and instead key references are provided. Through this format, this "8th" topic in the series focuses on the relevant risk factors, diagnostic considerations, prophylaxis, and treatment approaches relevant to rare mold infections in the pre- and post-transplant periods.
美国移植与细胞治疗学会实践指南委员会与其移植传染病特别兴趣小组合作，制定了一项针对非曲霉菌侵袭性霉菌的指南，这些霉菌在造血细胞移植（HCT）期间是罕见但致命的侵袭性真菌疾病。我们采用了纲要式方法，将这个广泛、异质性强且高度复杂的主题分解为一系列独立的常见问题（FAQ）和表格。成人和儿童传染病及HCT内容专家编写了常见问题并给出答案，最后确定了统一建议的主题。所有关于非曲霉菌侵袭性霉菌感染的证据均为非随机对照试验，且大多为III级，因此没有推荐等级，而是提供了关键参考文献。通过这种形式，本系列中的“第8个”主题聚焦于移植前后与罕见霉菌感染相关的风险因素、诊断考量、预防措施和治疗方法。
