Naz Rabia, Saqib Fatima
Faculty of Pharmacy, Bahauddin Zakariya University, 60800, Multan, Pakistan.
J Ethnopharmacol. 2025 Mar 13;343:119451. doi: 10.1016/j.jep.2025.119451. Epub 2025 Feb 7.
Tradescantia spathaceae Sw. (commonly referred to as the oyster plant, boat lily, or Moses in a basket) is classified within the family Commelinaceae. The fresh infusion of this plant is utilized for addressing renal issues. Its foliage is employed in the management of kidney stones, renal discomfort, kidney infections, and dysuria.
The aim of this research was to conduct pharmacological validation of T. spathaceae in relation to the treatment of disorders affecting the urinary system. In-vivo, in-vitro, and in-silico investigations were designed to demonstrate the possible advantages of T. spathaceae in renal protection and diuresis.
The pharmacologically active constituents of the ethanoic extract of T. spathaceae were analysed utilizing High-Performance Liquid Chromatography (HPLC). In-vivo experiments were directed to evaluate the potential benefits of T. spathaceae in facilitating diuresis, safeguarding the kidneys from cisplatin-induced toxicity, and inducing spasms in isolated bladder tissues to clarify its spasmolytic properties.
HPLC analysis of the hydroethanolic extract of T. spathaceae identified gallic acid, vanillic acid, and p-coumaric acid. This extract showed dose dependent relaxation of contractions induced by carbachol (1 μM), acetylcholine (Ach) (1 μM), and low potassium (25 mmol) in isolated strips of the urinary bladder. Its spasmolytic effects were comparable to the standard agents atropine and oxybutynin. In vivo studies demonstrated the extract's protective effects on the kidneys, along with anti-inflammatory and diuretic properties. Additionally, it offered protection against cisplatin-induced toxicity while promoting diuresis.
TSCR exhibited nephroprotective effects through diuretic, anti-inflammatory, and anti-muscarinic actions.
紫露草（通常被称为蚌兰、舟形百合或篮中摩西草）属于鸭跖草科。这种植物的新鲜浸剂用于治疗肾脏问题。其叶子用于治疗肾结石、肾脏不适、肾脏感染和排尿困难。
本研究的目的是对紫露草在治疗影响泌尿系统的疾病方面进行药理学验证。设计了体内、体外和计算机模拟研究，以证明紫露草在肾脏保护和利尿方面可能具有的优势。
利用高效液相色谱法（HPLC）分析紫露草乙酸提取物的药理活性成分。体内实验旨在评估紫露草在促进利尿、保护肾脏免受顺铂诱导的毒性以及诱导离体膀胱组织痉挛以阐明其解痉特性方面的潜在益处。
对紫露草水乙醇提取物的HPLC分析鉴定出了没食子酸、香草酸和对香豆酸。该提取物在离体膀胱条带中显示出对卡巴胆碱（1μM）、乙酰胆碱（Ach）（1μM）和低钾（25mmol）诱导的收缩具有剂量依赖性的松弛作用。其解痉作用与标准药物阿托品和奥昔布宁相当。体内研究表明该提取物对肾脏具有保护作用，同时具有抗炎和利尿特性。此外，它在促进利尿的同时还能保护免受顺铂诱导的毒性。
紫露草提取物通过利尿、抗炎和抗毒蕈碱作用表现出肾保护作用。
