Reji Shyama, Sankaraeswaran Malini, Ulagamathesan Venkatesan, Wesley Hannah, Ramesh Gowri, Srinivasan Shylaja, Misra Shivani, Mohan Anjana Ranjit, Unnikrishnan Ranjit, Mohan Viswanathan, Amutha Anandakumar
Madras Diabetes Research Foundation, Chennai, Tamil Nadu, India; University of Madras, Chennai, Tamil Nadu, India.
SRM Institute of Science and Technology, Kattankulathur, Chengalpattu District, Tamil Nadu, India.
Diabetes Res Clin Pract. 2025 Mar;221:112013. doi: 10.1016/j.diabres.2025.112013. Epub 2025 Feb 7.
BACKGROUND & AIM: The prevalence of young onset (≤30 years) type 2 diabetes (T2D) is increasing in South Asians, reflecting rise in childhood obesity. This systematic review analyses current data on thecohort prevalence of young onset T2D in South Asians.
PubMed, Scopus,Science Direct,and Ebscohost were searched for articles published between 1990 and 2024, anda manual search identified additional articles. This study included case series, cross-sectional, retrospective cohort, or case reports.
Out of 5073 studies, 26 eligible studies were found including three case reports. Seventeen studies were from India, five werefrom other South Asian countries (Pakistan, Bangladesh, Nepal, Maldives), and nine were on migrant South Asians residing in different countries (UK,USA,Qatar, Canada). The cohort prevalence of young onset T2D in South Asians ranged from 0.1 % to 28.3 % (India 0.4 to 26.8 %, other SA countries 0.1 to 28.3 %, and migrant South Asians 4.1 to 18.1 %).
The burden of T2D among native South Asian children and young adults is higher than among migrant South Asians. This contrasts with traditional perceptions that T2D primarily affects older individuals and the South Asian diaspora i.e., those who have migrated from South Asia.
在南亚地区，年轻发病（≤30岁）的2型糖尿病（T2D）患病率正在上升，这反映了儿童肥胖率的上升。本系统评价分析了有关南亚地区年轻发病T2D队列患病率的现有数据。
检索了PubMed、Scopus、Science Direct和Ebscohost数据库中1990年至2024年发表的文章，并通过手工检索确定了其他文章。本研究纳入了病例系列、横断面、回顾性队列或病例报告。
在5073项研究中，发现了26项符合条件的研究，其中包括3篇病例报告。17项研究来自印度，5项来自其他南亚国家（巴基斯坦、孟加拉国、尼泊尔、马尔代夫），9项是关于居住在不同国家的南亚移民（英国、美国、卡塔尔、加拿大）。南亚地区年轻发病T2D的队列患病率在0.1%至28.3%之间（印度为0.4%至26.8%，其他南亚国家为0.1%至28.3%，南亚移民为4.1%至18.1%）。
南亚本土儿童和年轻人中T2D的负担高于南亚移民。这与传统观念相反，传统观念认为T2D主要影响老年人和南亚侨民，即那些从南亚移民的人。
