Wang Jianjun, Chen Xi, He Wei, Zeng Xintao, Yang Pei, Gong Jianping, Wang Decai
Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Department of Hepatobiliary Surgery, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China.
Front Med (Lausanne). 2025 Jan 24;12:1511637. doi: 10.3389/fmed.2025.1511637. eCollection 2025.
Arm circumference (AC) is a measure of nutritional status and an indicator of the risk of developing diseases, such as metabolic disorders. However, its relationship with the prevalence of gallstone disease (GS), a metabolic disorder, is unknown. Consequently, this research sought to investigate the relationship between AC and the prevalence of GS among the general adult population in America.
Participant data were extracted from the National Health and Nutrition Examination Survey (NHANES) 2017-2020 cycle. GS was defined based on self-reported medical history. AC was measured following standardized protocols as the primary exposure variable. Multivariable logistic regression models were employed to assess the association between AC and GS. Dose-response relationships were evaluated using generalized additive models with smoothed curve fitting, and subgroup analyses were conducted to explore effect modification by key covariates such as age, sex, race, hypertension, diabetes, and body mass index.
Overall, a total of 8,081 participants were included in this study, with 849 reporting a history of GS. After accounting for potential confounders, we discovered that each centimeter increase in AC was linked to an 8% rise in the prevalence of GS (Odd ratio = 1.08, 95% confidence interval: 1.07-1.10). Dose-response curves demonstrated a positive linear relationship between AC and the prevalence of GS, which, according to the results of the subgroup analyses, was consistent in the vast majority of subgroups, although there were subtle differences.
AC exhibited a linear and positive association with the prevalence of GS. Although a causal relationship between AC and the prevalence of GS could not be established, our study provides strong new support for the potential role of AC in the health assessments of adult populations.
臂围（AC）是营养状况的一项衡量指标，也是诸如代谢紊乱等疾病发生风险的一个指标。然而，其与代谢紊乱疾病胆结石病（GS）患病率之间的关系尚不清楚。因此，本研究旨在调查美国普通成年人群中AC与GS患病率之间的关系。
从2017 - 2020年国家健康与营养检查调查（NHANES）周期中提取参与者数据。GS根据自我报告的病史来定义。按照标准化方案测量AC作为主要暴露变量。采用多变量逻辑回归模型评估AC与GS之间的关联。使用具有平滑曲线拟合的广义相加模型评估剂量反应关系，并进行亚组分析以探讨年龄、性别、种族、高血压、糖尿病和体重指数等关键协变量的效应修正。
总体而言，本研究共纳入8081名参与者，其中849人报告有GS病史。在考虑潜在混杂因素后，我们发现AC每增加1厘米，与GS患病率上升8%相关（比值比 = 1.08，95%置信区间：1.07 - 1.10）。剂量反应曲线显示AC与GS患病率之间呈正线性关系，亚组分析结果表明，尽管存在细微差异，但在绝大多数亚组中都是一致的。
AC与GS患病率呈线性正相关。虽然无法确定AC与GS患病率之间的因果关系，但我们的研究为AC在成年人群健康评估中的潜在作用提供了有力的新支持。
