Lv Guozheng, Wang Decai, Huang Yu, Shi Ruizi, Qin Chuan, Chen Xi, Zeng Xintao, Luo Hua, Yang Pei, Chen Sirui, Wang Jianjun
Department of Hepatobiliary Surgery, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of China, Mianyang, China.
Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Med (Lausanne). 2025 Jan 17;12:1487974. doi: 10.3389/fmed.2025.1487974. eCollection 2025.
We investigated the association between serum uric acid (SUA) levels and gallstone (GS) prevalence in adult women.
Participants' information were taken from the United States National Health and Nutrition Examination Survey (2017-2020). Logistic regression analysis and dose-response curve were used to assess the association between SUA levels and the prevalence of GS in adult women. Subgroup analyses were performed to investigate associations between SUA levels and age, ethnicity, body mass index, hypertension, and diabetes.
A total of 600 participants self-reported a history of GS. After adjusting for confounding, the prevalence of GS in adult women increased by 14% for every 1 mg/dL increase in SUA (odds ratio [OR]: 1.14, 95% confidence interval [CI]: 1.06, 1.22). Testing SUA as a categorical variable for sensitivity analyses indicated a 1.6-fold increase in the prevalence of GS in tertile 3 (OR=1.60, 95% CI: 1.25, 2.04) compared to tertile 1. Dose-response curves showed a nonlinear correlation between SUA levels and the prevalence of GS. Subgroup analyses indicated that SUA level was associated with an increased prevalence of GS in most subgroups, although subtle differences existed.
SUA was positively and non-linearly associated with the prevalence of GS in adult females. Despite the inability to clarify the causal relationship between them, our results remain interesting.
我们研究了成年女性血清尿酸（SUA）水平与胆结石（GS）患病率之间的关联。
参与者信息取自美国国家健康与营养检查调查（2017 - 2020年）。采用逻辑回归分析和剂量反应曲线来评估成年女性SUA水平与GS患病率之间的关联。进行亚组分析以研究SUA水平与年龄、种族、体重指数、高血压和糖尿病之间的关联。
共有600名参与者自述有GS病史。在调整混杂因素后，成年女性中SUA每升高1mg/dL，GS患病率增加14%（比值比[OR]：1.14，95%置信区间[CI]：1.06，1.22）。将SUA作为分类变量进行敏感性分析表明，与第一三分位数相比，第三三分位数中GS患病率增加了1.6倍（OR = 1.60，95% CI：1.25，2.04）。剂量反应曲线显示SUA水平与GS患病率之间存在非线性相关性。亚组分析表明，尽管存在细微差异，但在大多数亚组中SUA水平与GS患病率增加相关。
SUA与成年女性GS患病率呈正相关且为非线性关系。尽管无法阐明它们之间的因果关系，但我们的结果仍然很有意思。
