Gould P R, Gould I M
Trans R Soc Trop Med Hyg. 1985;79(1):67-9. doi: 10.1016/0035-9203(85)90239-1.
The records of 16 consecutive patients with proven cryptococcosis, admitted to the two referral hospitals in Harare over a 15-year period, were reviewed. 15 were cases of meningitis, one with spinal cord granuloma, and the 16th was an orbital osteomyelitis. There were eight children and eight adults with a marked male preponderance. There was an absence of any predisposing conditions. The common clinical signs and symptoms were headache, neck stiffness, fever, confusion or drowsiness, cranial nerve lesions and long tract signs. The diagnosis was rarely suspected on admission but was discovered during life in 15 patients, in 12 by finding the organism in the (CSF) cerebrospinal fluid, and in three by biopsy of affected tissue. 50% of patients presented with a predominance of polymorphs in the CSF. The mortality rate was very high (57%) but most died before adequate treatment could be given.
对哈拉雷两家转诊医院在15年期间收治的16例经证实患有隐球菌病的连续患者的记录进行了回顾。15例为脑膜炎病例，1例为脊髓肉芽肿，第16例为眼眶骨髓炎。有8名儿童和8名成人，男性占明显优势。不存在任何诱发因素。常见的临床体征和症状为头痛、颈部僵硬、发热、意识模糊或嗜睡、脑神经病变和长束征。入院时很少怀疑诊断，但15例患者在生前确诊，12例通过在脑脊液中发现病原体确诊，3例通过对受影响组织进行活检确诊。50%的患者脑脊液中多形核白细胞占优势。死亡率非常高（57%），但大多数患者在给予充分治疗之前死亡。
