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Antagonizing HFpEF by Targeting Fibrosis.

作者信息

Bann Glynnis Garry

机构信息

Department of Internal Medicine, Division of Cardiology and the Department of Molecular Biology, the Hamon Center for Regenerative Science and Medicine, and Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Center, University of Texas Southwestern Medical Center, Dallas, TX.

出版信息

Circulation. 2025 Feb 11;151(6):396-399. doi: 10.1161/CIRCULATIONAHA.124.072973. Epub 2025 Feb 10.

DOI:10.1161/CIRCULATIONAHA.124.072973
PMID:39928720
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12262591/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec45/12262591/8fcb91093b08/nihms-2091633-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec45/12262591/8fcb91093b08/nihms-2091633-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec45/12262591/8fcb91093b08/nihms-2091633-f0001.jpg

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本文引用的文献

1
Cardiac Reprogramming and Gata4 Overexpression Reduce Fibrosis and Improve Diastolic Dysfunction in Heart Failure With Preserved Ejection Fraction.心脏重编程和Gata4过表达可减少射血分数保留的心力衰竭中的纤维化并改善舒张功能障碍。
Circulation. 2025 Feb 11;151(6):379-395. doi: 10.1161/CIRCULATIONAHA.123.067504. Epub 2024 Dec 14.
2
Targeting HDAC6 to treat heart failure with preserved ejection fraction in mice.靶向 HDAC6 治疗射血分数保留型心力衰竭的小鼠模型。
Nat Commun. 2024 Feb 26;15(1):1352. doi: 10.1038/s41467-024-45440-7.
3
Heart Failure Epidemiology and Outcomes Statistics: A Report of the Heart Failure Society of America.心力衰竭流行病学与结局统计：美国心力衰竭学会报告
J Card Fail. 2023 Oct;29(10):1412-1451. doi: 10.1016/j.cardfail.2023.07.006. Epub 2023 Sep 26.
4
Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity.司美格鲁肽治疗射血分数保留的心力衰竭合并肥胖患者的疗效。
N Engl J Med. 2023 Sep 21;389(12):1069-1084. doi: 10.1056/NEJMoa2306963. Epub 2023 Aug 25.
5
Direct Reprogramming Improves Cardiac Function and Reverses Fibrosis in Chronic Myocardial Infarction.直接重编程改善慢性心肌梗死的心脏功能并逆转纤维化。
Circulation. 2023 Jan 17;147(3):223-238. doi: 10.1161/CIRCULATIONAHA.121.058655. Epub 2022 Dec 12.
6
Empagliflozin in Heart Failure with a Preserved Ejection Fraction.恩格列净治疗射血分数保留的心力衰竭。
N Engl J Med. 2021 Oct 14;385(16):1451-1461. doi: 10.1056/NEJMoa2107038. Epub 2021 Aug 27.
7
From Systemic Inflammation to Myocardial Fibrosis: The Heart Failure With Preserved Ejection Fraction Paradigm Revisited.从全身炎症到心肌纤维化：再探射血分数保留的心力衰竭。
Circ Res. 2021 May 14;128(10):1451-1467. doi: 10.1161/CIRCRESAHA.121.318159. Epub 2021 May 13.
8
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Nat Commun. 2021 Mar 16;12(1):1684. doi: 10.1038/s41467-021-21931-9.
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Nitrosative stress drives heart failure with preserved ejection fraction.硝化应激导致射血分数保留型心力衰竭。
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