Vahapoğlu Ayşe, Kaya Gök Ayfer, Çavuş Zuhal
Department of Anesthesiology and Intensive Care, University of Health Sciences, Gaziosmanpaşa Training Research Hospital, Istanbul, Turkey.
Medicine (Baltimore). 2025 Feb 7;104(6):e41472. doi: 10.1097/MD.0000000000041472.
The ideal timing for tracheostomy in patients undergoing prolonged mechanical ventilation (MV) in the intensive care unit (ICU) remains controversial. The present study aimed to provide an overview of the timing of percutaneous dilation tracheostomy performed in the ICU over a 5-year period, and the effect of this procedure on 28-day mortality. The study included patients who underwent early (≤14 days) (n = 112) and late (>14 days) (n = 171) tracheostomy during their follow-up in the ICU between 2018 and 2023. It is a single-center retrospective study. The diagnoses, comorbidities, MV duration, tracheostomy timing, tracheostomy indications, tracheostomy complications, ICU length of stay, hospital length of stay, extubation attempts, mortality, time to decannulation, and ICU discharge location were determined in both tracheostomy groups and compared. The effect of tracheostomy timing on mortality risk was evaluated using multivariate Cox regression analyses. In the early tracheostomy group, MV duration, ICU hospitalization, hospital stay, and extubation attempt were lower. The 28-day intensive care mortality rates were not statistically different between the early and late tracheostomy groups. Multivariate regression analysis showed that mortality risk increased with prolonged MV and tracheostomy complications. In terms of mortality rates in palliative care, mortality in the late tracheostomy group was significantly lower than in the early tracheostomy group. The study demonstrated that the timing of tracheostomy in the ICU had no effect on mortality risk in multivariate analysis. We believe that time is not the only limiting factor when considering tracheostomy and prospective randomized studies are needed.
在重症监护病房(ICU)接受长时间机械通气(MV)的患者中,气管切开术的理想时机仍存在争议。本研究旨在概述在5年期间ICU中进行经皮扩张气管切开术的时机,以及该手术对28天死亡率的影响。该研究纳入了2018年至2023年在ICU随访期间接受早期(≤14天)(n = 112)和晚期(>14天)(n = 171)气管切开术的患者。这是一项单中心回顾性研究。确定了两个气管切开术组的诊断、合并症、MV持续时间、气管切开术时机、气管切开术指征、气管切开术并发症、ICU住院时间、住院时间、拔管尝试次数、死亡率、拔管时间以及ICU出院地点,并进行了比较。使用多变量Cox回归分析评估气管切开术时机对死亡风险的影响。在早期气管切开术组中,MV持续时间、ICU住院时间、住院时间和拔管尝试次数较低。早期和晚期气管切开术组之间的28天重症监护死亡率无统计学差异。多变量回归分析表明,死亡风险随着MV延长和气管切开术并发症而增加。在姑息治疗的死亡率方面,晚期气管切开术组的死亡率显著低于早期气管切开术组。该研究表明,在多变量分析中,ICU气管切开术的时机对死亡风险没有影响。我们认为,在考虑气管切开术时,时间不是唯一的限制因素,需要进行前瞻性随机研究。