Dimitrov A, Veselinova A, Pavlov N, Nikolov N V, Belchev L
Vet Med Nauki. 1985;22(2):35-42.
A histopathologic study was carried out on lymph nodes and viscera of 98 cows and 28 heifers that responded positively in serologic examinations for leukosis. The animals did not exhibit clinical and paraclinical symptoms, neither were there found any morphologic changes characteristic of leukosis. There existed activation and proliferation of the reticuloendothelial tissue in the sinuses of the lymph nodes. The same response was shown by the endothelium of the capillaries in visceral organs. There was also metaplasia that concerned mainly the connective tissue cells of the lymph node trabeculas as well as the adventitial cells of the vascular walls. It was considered that the infection could be manifested morphologically as a reticuloendotheliosis. By its clinical course and morphologic manifestation bovine leukosis resembles some other virus diseases that have been systematized as "delayed virus infections'.
对98头母牛和28头小母牛的淋巴结及内脏进行了组织病理学研究，这些牛在白血病血清学检查中呈阳性反应。这些动物未表现出临床和亚临床症状，也未发现任何白血病特征性的形态学变化。淋巴结窦中的网状内皮组织存在活化和增殖。内脏器官毛细血管的内皮也有同样的反应。此外，主要涉及淋巴结小梁的结缔组织细胞以及血管壁外膜细胞的化生也存在。据认为，这种感染在形态学上可能表现为网状内皮增生症。从其临床病程和形态学表现来看，牛白血病类似于其他一些已被归类为“迟发性病毒感染”的病毒疾病。
