Türk Merve Ayık, Kömürcüoğlu Berna, Agüloğlu Nurşin, Çiftçi Tuğçe Doksöz, Fidan Mücahit, Çolak Sinan, Batum Özgür
From the Department of Pulmonology, University of Health Sciences Izmir Bozyaka Training and Research Hospital, Izmir, Turkey.
From the Department of Chest Diseases, University of Health Sciences Dr. Suat Seren Chest Diseases Hospital, Izmir, Turkey.
Ann Saudi Med. 2025 Jan-Feb;45(1):25-32. doi: 10.5144/0256-4947.2025.25. Epub 2025 Feb 6.
Small cell lung cancer (SCLC) is a lung malignancy with a poor prognosis and metastases at the time of diagnosis. There is limited experience using positron emission tomography/computed tomography (PET/CT) for SCLC diagnosis, staging, and follow-up.
Investigate the survival effect of primary tumor standardized uptake value max (SUVmax), SUV mean, metabolic tumor volume (MTV), total lesion glucose (TLG), bone marrow SUV (BM), and bone marrow to liver ratio (BLR) in SCLC.
Retrospective.
Single center in Turkey.
Patients who were cyto/histologically diagnosed with SCLC and had PET/CT simultaneous with the diagnosis were included in the study.
The effect of PET/CT parameters on overall survival (OS) and progression-free survival (PFS).
The 5-year OS median value was 14.62 months, and the 5-year PFS was 13.01 months. In Kaplan-Meier analysis, SUVmax, MTV, and TLG were statistically significant variables in OS (=.03; <.001; <.001, respectively). MTV and TLG were significant in PFS (<.001; =.0003, respectively). In the multivariate analysis, MTV was an independent PET/CT parameter associated with OS (=.003), stage of disease (=.012), SUVmax (=.003), MTV (=.016), and TLG (=.005) were significant variables in PFS.
In our study, MTV was an independent parameter that can be used to predict survival in SCLC. Considering the effect of MTV, a metabolic PET/CT parameter on survival, it can be recommended for clinical use as a standard measure of evaluation in PET/CT reports, just like SUVmax.
The first limitation was the single-center and retrospective design of the study. Due to the retrospective design of the study, weight loss, performance status, and smoking history could not be obtained from every patient. Second, inaccurate registration of PET and CT images due to patient respiratory movements may affect measurements.
小细胞肺癌（SCLC）是一种预后较差且在诊断时就已发生转移的肺部恶性肿瘤。使用正电子发射断层扫描/计算机断层扫描（PET/CT）进行SCLC诊断、分期和随访的经验有限。
研究原发性肿瘤标准化摄取值最大值（SUVmax）、平均SUV、代谢肿瘤体积（MTV）、总病变糖（TLG）、骨髓SUV（BM）以及骨髓与肝脏比值（BLR）对SCLC生存的影响。
回顾性研究。
土耳其的单中心。
纳入经细胞/组织学诊断为SCLC且在诊断时同时进行了PET/CT检查的患者。
PET/CT参数对总生存期（OS）和无进展生存期（PFS）的影响。
304例。
5年OS中位数为14.62个月，5年PFS为13.01个月。在Kaplan-Meier分析中，SUVmax、MTV和TLG在OS中是具有统计学意义的变量（分别为P =.03；P <.001；P <.001）。MTV和TLG在PFS中具有显著意义（分别为P <.001；P =.0003）。在多变量分析中，MTV是与OS相关的独立PET/CT参数（P =.003），疾病分期（P =.012）、SUVmax（P =.003）、MTV（P =.016）和TLG（P =.005）是PFS中的显著变量。
在我们的研究中，MTV是可用于预测SCLC生存的独立参数。考虑到MTV这一代谢PET/CT参数对生存的影响，它可像SUVmax一样，作为PET/CT报告中的标准评估指标推荐用于临床。
第一个局限性是研究的单中心和回顾性设计。由于研究的回顾性设计，无法从每位患者获取体重减轻情况、体能状态和吸烟史。其次，患者呼吸运动导致的PET和CT图像配准不准确可能会影响测量结果。
