Jiang Ying, Lu Rongrong, Shen Yuan, Zhou Qin, Ou Mengmeng, Du Zhiqiang, Zhu Haohao
Affiliated Mental Health Center of Jiangnan University, Wuxi Central Rehabilitation Hospital, Wuxi, 214151, Jiangsu, China.
Sci Rep. 2025 Feb 10;15(1):4984. doi: 10.1038/s41598-025-88260-5.
Analyze the use of antibacterial drugs and bacterial resistance in psychiatric hospital during the epidemic. Using the hospital information system and the National Antibacterial Drug Clinical Application Monitoring Network, we retrospectively collected data on the use of antibacterial drugs and bacterial resistance in psychiatric hospitals during the 2022 epidemic. During the 2022 epidemic, our hospital had an antibiotic use rate of 5.00%, a usage intensity of 3.07, a combined medication rate of 11.11%, a cumulative DDDs of 12,039.04, and antibiotic costs accounting for 3.95% of total drug costs. These are much lower than the levels in Jiangsu Province and nationwide. However, the rate of microbiological submission for antibacterial drug use was 77.78%, higher than that of Jiangsu Province and nationwide. The main antibiotics used in our hospital were third-generation cephalosporins, penicillins, and quinolone antibiotics, with the most commonly used being cefodizime, amoxicillin, and piperacillin-tazobactam. The results showed that Gram-negative bacteria mainly exhibited resistance to penicillins, cephalosporins, and quinolones, especially ampicillin, amoxicillin-clavulanic acid, ceftazidime, ceftriaxone, amikacin, and ciprofloxacin. Gram-positive bacteria mainly resisted penicillins, macrolides, and quinolones, especially penicillin, benzylpenicillin, erythromycin, levofloxacin, and ciprofloxacin. This study reveals a complex relationship between the rational use of antibacterial drugs and bacterial resistance in the psychiatric hospital. Although antimicrobial usage during the pandemic was generally appropriate, increased use in psychiatric settings correlated with rising bacterial resistance, thereby impacting treatment outcomes and patient prognosis. Therefore, it is recommended to enhance monitoring of bacterial resistance and regularly analyze resistance data to optimize antimicrobial use in psychiatric hospitals. This approach aims to ensure effective treatment while minimizing the development of resistant strains, ultimately improving the overall value of healthcare services.
分析疫情期间精神病医院抗菌药物的使用情况及细菌耐药性。利用医院信息系统和国家抗菌药物临床应用监测网，我们回顾性收集了2022年疫情期间精神病医院抗菌药物使用情况及细菌耐药性的数据。2022年疫情期间，我院抗生素使用率为5.00%，使用强度为3.07，联合用药率为11.11%，累计限定日剂量（DDDs）为12,039.04，抗生素费用占药品总费用的3.95%。这些数据远低于江苏省和全国水平。然而，抗菌药物使用的微生物送检率为77.78%，高于江苏省和全国水平。我院使用的主要抗生素为第三代头孢菌素、青霉素类和喹诺酮类抗生素，最常用的是头孢地嗪、阿莫西林和哌拉西林-他唑巴坦。结果显示，革兰阴性菌主要对青霉素类、头孢菌素类和喹诺酮类耐药，尤其是氨苄西林、阿莫西林-克拉维酸、头孢他啶、头孢曲松、阿米卡星和环丙沙星。革兰阳性菌主要对青霉素类、大环内酯类和喹诺酮类耐药，尤其是青霉素、苄星青霉素、红霉素、左氧氟沙星和环丙沙星。本研究揭示了精神病医院抗菌药物合理使用与细菌耐药性之间的复杂关系。虽然疫情期间抗菌药物的使用总体上是合理的，但精神病医院抗菌药物使用的增加与细菌耐药性的上升相关，从而影响治疗效果和患者预后。因此，建议加强细菌耐药性监测，定期分析耐药数据，以优化精神病医院抗菌药物的使用。这种方法旨在确保有效治疗，同时尽量减少耐药菌株的产生，最终提高医疗服务的整体价值。
