Hashimoto Yosuke, Campbell Matthew
Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland.
Adv Exp Med Biol. 2025;1468:447-451. doi: 10.1007/978-3-031-76550-6_73.
Tight junctions are physical barriers that limit the paracellular diffusion of solutes and ions. The blood-retina barriers are cellular barriers composed of tight junctions established in retinal pigment epithelial (RPE) cells and retinal endothelial cells to maintain retinal homeostasis. Claudins are the major components of tight junctions, and their dysregulation leads to impaired blood-retina barrier integrity, resulting in retinal diseases with concomitant local inflammation. In this chapter, we introduce two important claudins, claudin-5 and -19, and briefly explain how decreased expression of these claudins is associated with the progress of diabetic retinopathy (DR) and age-related macular degeneration (AMD) by compromising the blood-retina barriers.
紧密连接是限制溶质和离子细胞旁扩散的物理屏障。血视网膜屏障是由视网膜色素上皮（RPE）细胞和视网膜内皮细胞中建立的紧密连接组成的细胞屏障，以维持视网膜内环境稳定。闭合蛋白是紧密连接的主要成分，其失调会导致血视网膜屏障完整性受损，从而引发伴有局部炎症的视网膜疾病。在本章中，我们介绍两种重要的闭合蛋白，即闭合蛋白-5和-19，并简要解释这些闭合蛋白的表达降低如何通过损害血视网膜屏障而与糖尿病视网膜病变（DR）和年龄相关性黄斑变性（AMD）的进展相关。
