Garner Mary Anne, Gross Alecia K
Department of Neurobiology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Adv Exp Med Biol. 2025;1468:453-457. doi: 10.1007/978-3-031-76550-6_74.
Nuclear Distribution Protein C (NUDC) has been studied extensively for its role in mitosis. In addition to its well-established role in dynein-mediated nuclear migration, NUDC also plays a role in postmitotic cells. NUDC affects dynein-mediated protein and organelle trafficking and also stabilizes the actin-modulating protein, cofilin (CFL1), thereby affecting cytoskeletal reorganization. This mini-review will cover the known role of NUDC in mitosis as well as its role in actin cytoskeletal reorganization and in protein and organelle trafficking in nondividing cells, as well as update findings on the effect of a loss of NUDC on rod photoreceptors.
核分布蛋白C（NUDC）因其在有丝分裂中的作用而被广泛研究。除了在动力蛋白介导的核迁移中已确立的作用外，NUDC在有丝分裂后细胞中也发挥作用。NUDC影响动力蛋白介导的蛋白质和细胞器运输，还能稳定肌动蛋白调节蛋白丝切蛋白（CFL1），从而影响细胞骨架重组。这篇小型综述将涵盖NUDC在有丝分裂中的已知作用，以及其在非分裂细胞的肌动蛋白细胞骨架重组、蛋白质和细胞器运输中的作用，同时更新关于NUDC缺失对视杆光感受器影响的研究结果。
