基于修饰丝网印刷碳电极的厄洛替尼检测分子印迹电化学传感器的研制。
Development of a molecularly imprinted electrochemical sensor for erlotinib detection using a modified screen-printed carbon electrode.
作者信息
Ahmed Saif Ali, Roushani Mahmoud, Karazan Zahra Mirzaei
机构信息
Department of Chemistry, Faculty of Sciences, Ilam University, P. O. BOX, Ilam, 69315-516, Iran.
出版信息
Mikrochim Acta. 2025 Feb 10;192(3):138. doi: 10.1007/s00604-025-07012-4.
A screen-printed carbon electrode (SPCE) based on a molecularly imprinted polymer (MIP) technique has been modified to provide detection of erlotinib (ERL). For this purpose, the pyrogallol (PG) monomer in the presence of ERL as an analyte has been electropolymerized on the SPCE surface. The introduced sensor has been characterized through differential pulse voltammetry (DPV), cyclic voltammetry (CV), and field emission scanning electron microscopy (FESEM) methods. The modified SPCE allowed ERL detection in a linear range of 0.05-800 nM with a limit of detection (LOD) of 0.016 nM. The applicability of modified SPCE was successfully investigated in serum samples. Lastly, for validation, sensor performance was compared with high-performance liquid chromatography (HPLC). The introduced sensor exhibited good application in the biomedical field.
一种基于分子印迹聚合物（MIP）技术的丝网印刷碳电极（SPCE）已被改进用于检测厄洛替尼（ERL）。为此，在作为分析物的ERL存在下，邻苯三酚（PG）单体在SPCE表面进行了电聚合。通过差分脉冲伏安法（DPV）、循环伏安法（CV）和场发射扫描电子显微镜（FESEM）方法对引入的传感器进行了表征。修饰后的SPCE能够在0.05 - 800 nM的线性范围内检测ERL，检测限（LOD）为0.016 nM。成功研究了修饰后的SPCE在血清样本中的适用性。最后，为了进行验证，将传感器性能与高效液相色谱法（HPLC）进行了比较。引入的传感器在生物医学领域表现出良好的应用前景。
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