Pan Lili, Xu Zhengrong, Li Yining, Cai Guoen, Gao Haibing, Lin Shenglong
Fujian Provincial Key Laboratory on Hematology, Fujian Institute of Hematology, Fujian Medical University Union Hospital, Fuzhou, China.
Translational Medicine Center on Hematology, Fujian Medical University, Fuzhou, China.
Front Nutr. 2025 Jan 27;12:1537855. doi: 10.3389/fnut.2025.1537855. eCollection 2025.
Chronic liver diseases (CLD) continue to pose a significant global burden, potentially exacerbated by pro-inflammatory diets. This study explores the relationship between the Dietary Inflammatory Index (DII), a measure of dietary inflammatory potential, and CLD risk.
Utilizing data from the UK Biobank cohort, we assessed the dietary information and calculated the DII for each participant. Cox proportional hazards models and Fine-Gray competing risk models were employed to evaluate the association between DII and CLD incidence, adjusting for potential confounders.
Our analysis included 121,329 participants with a median follow-up of 604.43 weeks, during which 4,018 developed CLD. A higher DII, indicating a more inflammatory diet, was associated with a 16% increased risk of CLD [hazard ratio (HR) = 1.162, = 0.001], with each unit increase in DII elevating the risk by 3.3% (HR: 1.033, < 0.001). A significant linear association between DII and CLD was observed. Competing risk analyses, which accounted for cirrhosis, liver cancer, and death, supported these findings. Subgroup analyses confirmed the robustness of the DII's association across various demographic and lifestyle factors. Moreover, a higher DII was positively associated with the progression of CLD to cirrhosis. Sensitivity analyses, including energy-adjusted DII and typical dietary DII, reinforced our results. Additionally, adherence to anti-inflammatory dietary patterns, as indicated by higher Healthy Eating Index 2020 and Mediterranean Diet Score values, was inversely associated with CLD risk.
Our study highlights the potential benefits of adopting anti-inflammatory diets as a strategy for the prevention and management of CLD. Comprehensive dietary interventions may play a pivotal role in mitigating the global burden of CLD.
慢性肝病（CLD）仍然是一个重大的全球负担，促炎饮食可能会加剧这一负担。本研究探讨了饮食炎症指数（DII）（一种衡量饮食炎症潜力的指标）与CLD风险之间的关系。
利用英国生物银行队列的数据，我们评估了每位参与者的饮食信息并计算了DII。采用Cox比例风险模型和Fine-Gray竞争风险模型来评估DII与CLD发病率之间的关联，并对潜在的混杂因素进行了调整。
我们的分析纳入了121329名参与者，中位随访时间为604.43周，在此期间有4018人患上了CLD。较高的DII表明饮食炎症性更强，与CLD风险增加16%相关[风险比（HR）=1.162，P=0.001]，DII每增加一个单位，风险就会升高3.3%（HR：1.033，P<0.001）。观察到DII与CLD之间存在显著的线性关联。考虑到肝硬化、肝癌和死亡的竞争风险分析支持了这些发现。亚组分析证实了DII在各种人口统计学和生活方式因素中的关联具有稳健性。此外，较高的DII与CLD进展为肝硬化呈正相关。敏感性分析，包括能量调整后的DII和典型饮食DII，强化了我们的结果。此外，较高的2020年健康饮食指数和地中海饮食评分所表明的抗炎饮食模式依从性与CLD风险呈负相关。
我们的研究强调了采用抗炎饮食作为预防和管理CLD策略的潜在益处。全面的饮食干预可能在减轻CLD的全球负担方面发挥关键作用。
