[Cancerous and precancerous changes in the tumor margin areas of patients with bladder cancers].

In histologically investigated tumour marginal biopsies of 68 patients with carcinomas of the urinary bladder a great number of findings was detected, which have a decisive influence on the prognosis. Degree of severity and frequency of these changes increase with reducing degree of differentiation of tumours. Hyperplasias of the urothelium, papillary formations and low-degree urothelial dysplasias are not easily to be estimated in the evaluation of their dignity in connection with highly differentiated papillary carcinomas of the urothelium. Multiple biopsies are the prerequisite for a modern therapy planning, in which case the tumour marginal area is of particular importance.