Luo Fang, Chen Tianyi, Chen Song, Bai Ding, Li Xinyi
State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Bone. 2025 Apr;193:117423. doi: 10.1016/j.bone.2025.117423. Epub 2025 Feb 9.
Hyperactivation of osteoclasts has been identified as a significant etiological factor in several bone resorption-related disorders, including osteoporosis, periodontitis, arthritis, and bone metastasis of tumors. It has been demonstrated that the severity of these diseases is influenced by lipids that regulate osteoclast differentiation and activity through specific signaling pathways and cytokine levels. The regulatory mechanisms of different types of lipids on osteoclastogenesis vary across diverse disease contexts in bone resorption regulated by osteoclasts. This review presents an overview of the mechanisms underlying osteoclast formation and summarizes the pathways through which various lipids regulate osteoclastogenesis in different pathological contexts. We also discuss effective therapeutic strategies for osteolytic diseases based on modulation of lipid metabolism.
破骨细胞的过度激活已被确定为几种与骨吸收相关疾病的重要病因，包括骨质疏松症、牙周炎、关节炎和肿瘤骨转移。已经证明，这些疾病的严重程度受脂质影响，这些脂质通过特定的信号通路和细胞因子水平调节破骨细胞的分化和活性。在破骨细胞调节的骨吸收过程中，不同类型的脂质对破骨细胞生成的调节机制在不同疾病背景下有所不同。本文综述了破骨细胞形成的潜在机制，并总结了各种脂质在不同病理背景下调节破骨细胞生成的途径。我们还讨论了基于脂质代谢调节的溶骨性疾病的有效治疗策略。
