Yang Dan, Xu Hai-Xia, Wang Wen-Jun, Yin Zhong-Ping, Chen Ji-Guang, Yuan En, Zhang Qing-Feng
Jiangxi Key Laboratory of Natural Product and Functional Food, College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang, China.
College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
Mol Nutr Food Res. 2025 Mar;69(6):e202400756. doi: 10.1002/mnfr.202400756. Epub 2025 Feb 11.
Roselle extract (RE) is rich in anthocyanins and chlorogenic acids. This study investigated the health-promoting effects of RE on lipid metabolism, oxidative stress, glycometabolism, and gut microbiota in obese mice fed a high-fat diet (HFD). The obesity model was induced by feeding mice a HFD, with RE supplementation added to their drinking water at concentrations of 2 and 4 mg/mL for 12 weeks. RE significantly reduced body weight gain and fat accumulation compared to the control group, alleviated hepatic steatosis, and improved insulin sensitivity. Additionally, RE restored antioxidative enzyme activities such as SOD and GSH-PX while reducing MDA levels. Transcriptomic analysis of the liver was performed to evaluate gene expression related to lipid metabolism, particularly in the PPAR signaling pathway. Gut microbiota analysis showed that RE increased beneficial bacteria and reduced the Firmicutes-to-Bacteroidetes ratio, suggesting an improvement in gut dysbiosis caused by the HFD. RE enhanced lipid metabolism, reduced oxidative stress, and improved insulin sensitivity in obese mice, potentially through modulation of the PPAR signaling pathway and gut microbiota, suggesting its potential as a therapeutic candidate for obesity-related metabolic disorders.
玫瑰茄提取物（RE）富含花青素和绿原酸。本研究调查了RE对高脂饮食（HFD）喂养的肥胖小鼠脂质代谢、氧化应激、糖代谢和肠道微生物群的健康促进作用。通过给小鼠喂食HFD诱导肥胖模型，同时在其饮用水中添加浓度为2和4mg/mL的RE，持续12周。与对照组相比，RE显著降低了体重增加和脂肪堆积，减轻了肝脏脂肪变性，并改善了胰岛素敏感性。此外，RE恢复了超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH-PX）等抗氧化酶的活性，同时降低了丙二醛（MDA）水平。对肝脏进行转录组分析以评估与脂质代谢相关的基因表达，特别是在过氧化物酶体增殖物激活受体（PPAR）信号通路中。肠道微生物群分析表明，RE增加了有益细菌并降低了厚壁菌门与拟杆菌门的比例，表明改善了由HFD引起的肠道生态失调。RE增强了肥胖小鼠的脂质代谢，降低了氧化应激，并改善了胰岛素敏感性，可能是通过调节PPAR信号通路和肠道微生物群实现的，这表明其作为肥胖相关代谢紊乱治疗候选药物的潜力。
