Department of Biotechnology and Laboratory Science in Medicine, National Yang-Ming University, No. 155, Sec. 2, Linong St., Beitou District, Taipei, 11221, Taiwan.
Departments of Clinical Pathology, Cheng Hsin General Hospital, Taipei, 11221, Taiwan.
BMC Complement Med Ther. 2020 Dec 10;20(1):376. doi: 10.1186/s12906-020-03171-4.
Obesity and its associated diseases have become a major world-wide health problem. Purple-leaf Tea (Camellia sinensis L.) (PLT), that is rich of anthocyanins, has been shown to have preventive effects on obesity and metabolic disorders. The intestinal microbiota has been shown to contribute to inflammation, obesity, and several metabolic disorders. However, whether PLT consumption could prevent obesity and diet-induced metabolic diseases by modulating the gut microbiota, is not clearly understood.
In this study, six-week-old male C57BL/6 J mice were fed a normal diet (ND) or a high fat diet (HFD) without or with PLT for 10 weeks.
PLT modulated the gut microbiota in mice and alleviated the symptoms of HFD-induced metabolic disorders, such as insulin resistance, adipocyte hypertrophy, and hepatic steatosis. PLT increased the diversity of the microbiota and the ratio of Firmicutes to Bacteroidetes. f_Barnesiellaceae, g_Barnesiella, f_Ruminococcaceae, and f_Lachnospiraceae were discriminating faecal bacterial communities of the PLT mice that differed from the HFD mice.
These data indicate that PLT altered the microbial contents of the gut and prevented microbial dysbiosis in the host, and consequently is involved in the modulation of susceptibility to insulin resistance, hepatic diseases, and obesity that are linked to an HFD.
肥胖及其相关疾病已成为全球性的重大健康问题。富含花青素的紫叶茶（Camellia sinensis L.）已被证明对肥胖和代谢紊乱具有预防作用。肠道微生物群已被证明与炎症、肥胖和多种代谢紊乱有关。然而，紫叶茶消费是否可以通过调节肠道微生物群来预防肥胖和饮食引起的代谢疾病，目前尚不清楚。
本研究中，6 周龄雄性 C57BL/6J 小鼠分别用正常饮食（ND）或高脂饮食（HFD）喂养 10 周，其中 HFD 组可额外补充紫叶茶。
紫叶茶调节了小鼠的肠道微生物群，缓解了 HFD 引起的代谢紊乱症状，如胰岛素抵抗、脂肪细胞肥大和肝脂肪变性。紫叶茶增加了微生物群的多样性和厚壁菌门与拟杆菌门的比例。f_Barnesiellaceae、g_Barnesiella、f_Ruminococcaceae 和 f_Lachnospiraceae 是区分 HFD 小鼠和紫叶茶小鼠粪便细菌群落的特征菌属。
这些数据表明，紫叶茶改变了肠道微生物的含量，防止了宿主的微生物失调，从而参与了对胰岛素抵抗、肝脏疾病和肥胖的易感性的调节，这些都与 HFD 有关。
