Lunn G, Sansone E B
Am Ind Hyg Assoc J. 1985 Mar;46(3):111-4. doi: 10.1080/15298668591394518.
It has been reported that dimethyl sulfate (DMS) can be degraded with sodium hydroxide solution (1 mol/L), sodium carbonate solution (1 mol/L), or ammonium hydroxide solution (1.5 mol/L). This has now been confirmed. Complete destruction of undiluted DMS or DMS in solvents miscible with water (methanol, ethanol, DMSO, DMF, acetone) or solvents partially miscible or immiscible with water (toluene, p-xylene, benzene, 1-pentanol, ethyl acetate, chloroform, carbon tetrachloride, acetonitrile) could be obtained using any of the above methods. Reaction times were 15 min after homogeneity was obtained for undiluted DMS, 15 min for solutions in methanol, ethanol, DMSO, and DMF, one hour for solutions in acetone, three hours for acetonitrile, and one day for the other solvents listed above. The final reaction mixtures were tested for mutagenicity, and when the solutions were not cytotoxic, no mutagenic response was obtained. DMS in solution was determined by a colorimetric method. The products of the reactions were found to be methanol when NaOH and Na2CO3 were used and methylamine, dimethylamine, trimethylamine, and methanol when ammonium hydroxide was used. The stability of DMS in various solvents was also determined.
据报道，硫酸二甲酯（DMS）可用氢氧化钠溶液（1mol/L）、碳酸钠溶液（1mol/L）或氢氧化铵溶液（1.5mol/L）降解。现已证实这一点。使用上述任何一种方法均可完全破坏未稀释的DMS或与水混溶的溶剂（甲醇、乙醇、二甲基亚砜、二甲基甲酰胺、丙酮）中的DMS，或与水部分混溶或不混溶的溶剂（甲苯、对二甲苯、苯、1-戊醇、乙酸乙酯、氯仿、四氯化碳、乙腈）中的DMS。对于未稀释的DMS，均匀后反应时间为15分钟；甲醇、乙醇、二甲基亚砜和二甲基甲酰胺溶液的反应时间为15分钟；丙酮溶液的反应时间为1小时；乙腈溶液的反应时间为3小时；上述其他溶剂的反应时间为1天。对最终反应混合物进行致突变性测试，当溶液无细胞毒性时，未获得致突变反应。溶液中的DMS通过比色法测定。发现使用NaOH和Na2CO3时反应产物为甲醇，使用氢氧化铵时反应产物为甲胺、二甲胺、三甲胺和甲醇。还测定了DMS在各种溶剂中的稳定性。
