Alotiby Amna A
Department of Haematology and Immunology, College of Medicine, Umm Al-Qura University, Makkah, SAU.
Cureus. 2025 Jan 12;17(1):e77317. doi: 10.7759/cureus.77317. eCollection 2025 Jan.
Alopecia areata is an autoimmune disorder characterized by hair loss in defined patches. Genetic factors are considered primary contributors to the onset and exacerbation of certain conditions. However, environmental triggers, particularly psychological stress, also play a significant role. This case report presents a 28-year-old woman with no prior history of autoimmune or immune-related conditions who developed severe alopecia areata following prolonged emotional stress. Despite the absence of systemic or nutritional deficiencies, she experienced significant hair loss, which improved with 5% Minoxidil and psychological stress management. However, a relapse occurred after another period of acute stress, highlighting the relationship between psychological stress and disease progression. This case underscores the need for a comprehensive treatment approach, combining pharmacological interventions like Minoxidil with stress reduction strategies to manage stress-induced autoimmune disorders and prevent relapses effectively. Such a combined approach is crucial in treating and managing alopecia areata, especially in patients with psychological stress triggers.
斑秃是一种自身免疫性疾病,其特征是在特定部位出现脱发。遗传因素被认为是某些疾病发病和加重的主要因素。然而,环境诱因,尤其是心理压力,也起着重要作用。本病例报告介绍了一名28岁女性,她既往无自身免疫或免疫相关疾病史,在长期情绪压力后出现严重斑秃。尽管没有全身性或营养缺乏,但她仍经历了严重脱发,使用5%米诺地尔和心理压力管理后脱发情况有所改善。然而,在另一段急性压力期后病情复发,突出了心理压力与疾病进展之间的关系。本病例强调了综合治疗方法的必要性,将米诺地尔等药物干预与减压策略相结合,以有效管理压力诱发的自身免疫性疾病并预防复发。这种联合方法对于治疗和管理斑秃至关重要,尤其是对于有心理压力诱因的患者。