Saner G, Dağoğlu T, Ozden T
Am J Clin Nutr. 1985 May;41(5):1042-4. doi: 10.1093/ajcn/41.5.1042.
The study was designed to investigate the manganese (Mn) status of mothers and their offspring at delivery. Hair Mn concentrations in 31 full-term, 18 preterm and 12 newborn infants with congenital malformations and their mothers were determined by the flameless atomic absorption technique. Both in infants with congenital malformations and their mothers, hair Mn levels were significantly lower than the full-term and preterm infant-mother pairs. With the exception of mothers of infants with congenital malformations, hair Mn concentrations in mothers were significantly higher as compared with their infants. Low hair Mn concentrations of infants with congenital malformations and their mothers may possibly reflect a state of Mn deficiency in these women. These results imply that 1) Mn deficiency may play a role as one potential factor in intrauterine malformations, 2) Mn is supplied to the fetus by a homeostatic mechanism which is mainly dependent on the Mn status of the mother, 3) prenatal Mn analysis in maternal hair may prove to be a reliable indicator for the risk of intrauterine malformations.
该研究旨在调查分娩时母亲及其后代的锰（Mn）状况。采用无火焰原子吸收技术测定了31名足月、18名早产以及12名患有先天性畸形的新生儿及其母亲头发中的锰浓度。患有先天性畸形的婴儿及其母亲的头发锰水平均显著低于足月和早产的母婴对。除了患有先天性畸形婴儿的母亲外，母亲头发中的锰浓度显著高于其婴儿。患有先天性畸形的婴儿及其母亲头发锰浓度较低可能反映了这些女性存在锰缺乏状态。这些结果表明：1）锰缺乏可能是宫内畸形的一个潜在因素；2）锰通过一种主要依赖母亲锰状况的稳态机制供应给胎儿；3）母亲头发中的产前锰分析可能是宫内畸形风险的可靠指标。
