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卵泡直径与排卵前代谢特征之间的相关性 。 （你提供的原文似乎不完整，后面应该还有具体的研究对象等相关内容）

Correlation between follicle diameter and pre-ovulatory metabolic profile in .

作者信息

Yan Jiuru, Fu Yuxin, Lan Lan, Zhang Huizhu, Huang Ling, Wang Yaying, Xiong Xianrong, Yin Shi, Li Jian, He Honghong

机构信息

Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Ministry of Education, Chengdu, China.

College of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu, China.

出版信息

Front Vet Sci. 2025 Jan 28;12:1498703. doi: 10.3389/fvets.2025.1498703. eCollection 2025.

DOI:10.3389/fvets.2025.1498703
PMID:39936077
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11811112/
Abstract

INTRODUCTION

In this study, we investigated the metabolic profiles of yak () follicles during the development period from the perspective of metabolomics, aiming to screen out the differential metabolites of yak follicles in different sizes and potential pathways during yak follicle development and to provide a basis for the study of follicle development and developmental mechanisms in the further stage of development.

METHODS

A total of 20 four-year-old female yaks were selected, and follicles of different sizes were collected after slaughter and divided into d < 3 mm, 3-6 mm and d > 6 mm. The follicular fluid was collected, 6 replicates per group and subjected to LC-MS assay, combined with multidimensional and unidimensional statistical analyses to screen the differential metabolites between follicles of different sizes. Differential metabolites enriched KEGG pathways to screen the pathways that might be related to follicle development.

RESULTS

We found that most of the metabolites were mainly enriched in amino acid metabolism pathways, energy metabolism pathways and other pathways of cofactor synthesis, and that during the development of the small follicle to the large follicle, 2-Lysophosphatidylcholine, PC (17:0/0:0), PC (16:0/0:0), and LysoPC (18:0/0:0) were down-regulated; Dioctyl succinate, P-Coumaraldehyde, ISOPRENE, L-Isoleucine, Dioctyl succinate up-regulated.

CONCLUSION

These results suggest that amino acid metabolism, the production of steroid hormones and their metabolites, and the metabolic activity of granulosa cells play important roles in follicle development. The results provide a theoretical basis for further exploration of follicular development in yak.

摘要

引言

在本研究中，我们从代谢组学的角度研究了牦牛卵泡发育时期的代谢谱，旨在筛选出不同大小牦牛卵泡的差异代谢物以及牦牛卵泡发育过程中的潜在途径，为进一步研究卵泡发育及其发育机制提供依据。

方法

选取20头4岁雌性牦牛，屠宰后收集不同大小的卵泡并分为直径<3mm、3 - 6mm和直径>6mm三组。收集卵泡液，每组6个重复样本，进行液相色谱 - 质谱分析，并结合多维和一维统计分析来筛选不同大小卵泡之间的差异代谢物。对差异代谢物进行KEGG通路富集分析，以筛选可能与卵泡发育相关的通路。

结果

我们发现大多数代谢物主要富集在氨基酸代谢途径、能量代谢途径和其他辅因子合成途径中，并且在小卵泡发育到大卵泡的过程中，2 - 溶血磷脂酰胆碱、PC(17:0/0:0)、PC(16:0/0:0)和溶血PC(18:0/0:0)下调；琥珀酸二辛酯、对香豆醛、异戊二烯、L - 异亮氨酸、琥珀酸二辛酯上调。

结论

这些结果表明氨基酸代谢、类固醇激素及其代谢产物的产生以及颗粒细胞的代谢活性在卵泡发育中起重要作用。研究结果为进一步探索牦牛卵泡发育提供了理论依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01b2/11811112/f3530933d170/fvets-12-1498703-g012.jpg
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