You Li, Wang Min, Liu Xuexue, Song Miao, Zhou Jiahong, Feng Jia, Liu Jinbo
Department of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University. Sichuan Province Engineering Technology Research Center of Molecular Diagnosis of Clinical Diseases. Molecular Diagnosis of Clinical Diseases Key Laboratory of Luzhou, Sichuan, China.
Future Oncol. 2025 Feb;21(5):593-603. doi: 10.1080/14796694.2024.2447813. Epub 2024 Dec 29.
Breast cancer (BC) is a global women's health concern, with ongoing research to address diagnostic and treatment challenges. Understanding the developmental mechanisms is vital for improved clinical prevention and treatment strategies. Mitochondria, undergo dynamic processes like fission and fusion, regulated by proteins like Dynamic-related protein 1 (DRP1). DRP1 plays a key role in mitochondrial fission, a process associated with BC development. This study aims to explore the impact of DRP1 on BC growth, assessing its potential as a therapeutic target. The findings could contribute to a better understanding of mitochondria-related molecular mechanisms in BC development and guide the identification of clinical drug targets.
乳腺癌（BC）是一个全球女性健康问题，目前正在进行研究以应对诊断和治疗挑战。了解其发育机制对于改进临床预防和治疗策略至关重要。线粒体经历诸如裂变和融合等动态过程，由动力相关蛋白1（DRP1）等蛋白质调控。DRP1在线粒体裂变中起关键作用，这一过程与乳腺癌的发展相关。本研究旨在探讨DRP1对乳腺癌生长的影响，评估其作为治疗靶点的潜力。这些发现有助于更好地理解乳腺癌发展中线粒体相关的分子机制，并指导临床药物靶点的识别。
